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| rdfs:seeAlso
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| Description
| - The project is targeted to synthesis of new fused heterocyclic compounds with application of compounds with allenyl synthon as substrates. Basic target of the project is connected with preparation of allenylaldehydes, allenyloximes, allenylamines via propargyl(vinyl)ethers. Next 1,4-diazadienes, nitrones, symmetrical and nonsymmetrical alenylazines will be prepared. The center of our interest will be derivatives of natural alkaloid withasomnine, they are expected having interesting biological properties. Such properties are expected mainly for compounds with adamantyl or a large planar substitution like naphtyl, anthranyl etc. The introduction of adamantyl skeleton could lead to a formation of new flu treatment agent. On the other hand introduction of a large planar substitution might lead to new compounds with significant cytotoxic activity. (en)
- Hlavním cílem projektu je příprava sloučenin s allenovým synthonem a studium jejich vlastností zejména v cyklizačních reakcích vedoucích ke kondensovaným heterocyklickým sloučeninám. Dále se zamýšlí studium stability a reaktivity takto získaných nových heterocyklických sloučenin.
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| Title
| - Allenyl synthon in synthesis of heterocyclic compounds (en)
- Allenový synthon v přípravě heterocyklických sloučenin
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - allen, azin, cykloadice, criss-cross, 1,3-dipol (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - The project gone according to plan both in terms of expertise and in terms of disbursement of funds. (en)
- Řešení projektu proběhlo podle plánu jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - 1
- allen
- azin
- criss-cross
- cykloadice
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| is http://linked.open...vavai/riv/projekt
of | - Dihydropyrrolo[1,2-b]pyrazoles. Synthesis of New Derivatives and Their Biological Evaluation
- Synthesis of new fused five-membered heterocycles and pyrrolidino[1,2-b]pyrazoles by thermal 1,3-dipolar cycloaddition reactions of non-symmetrical allenyl azines with alkynes as dipolarophiles
- One-pot tranformations of allenyloxime to stable functionalyzed cyclic nitrones
- 1,3-Dipolar cycloadditions of new 2,5-bifunctionalized 5-membered cyclic nitrones
- Caged proton sponges in base-catalyzed reactions
- New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA
- Preparation and basicity investigation of caged 'proton sponges'
- Unexpected Heterocyclic Products from Cycloaddition Reactions of Nonsymmetrical Allenyl Aldoketazines with Substituted Alkynes
- Substituted homoallenyl aldehydes and their derivatives. Part 1: Homoallenyl aldehydes and protected hydrazones
- Substituted homoallenyl aldehydes and their derivatives. Part 2: Azines
- Synthesis, activity and interaction of nitrone functionalized PAH derivatives
- Dihydropyrrolo[1,2-b]pyrazoles with potential biological activity
- Dihydropyrrolo[1,2-b]pyrazoles: withasomnine and related compounds
- Homoallenyl azines in criss-cross cycloaddition reactions
- Unexpected products of combined intra-intermolecular criss-cross cycloaddition of non-symmetrical allenyl azines with alkynes
- Cykloadičné reakcie nesymetrických allenyl ketazinov s vybranými alkýnmi
- Rearrangement of fused tetracyclic heterocycles induced by alkyl halides and formation of a new type of %22proton sponge%22
- One-pot, three-component synthesis of five-membered cyclic nitrones by addition/cyclization/condensation domino reaction
- Diverse chemical behaviour of 2-hydroxy functionalized pyrroline-1-oxide
- Synthesis of adamantane-containing heterocycles
- 1,3-Dipolar cycloadditions of new functionalized cyclic nitrones
- Homoallenyl aldehyde - general source for new heterocyclic compounds
- Synthesis of new dihydropyrrolo[1,2-b]pyrazole derivatives and their biological properties
- A new and facile synthesis of methyl 3-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxylate
- Allenyl Synthon in Synthesis of Adamantane Substituted Heterocycles
- A novel multicomponent approach to functionalized 5-membered cyclic nitrones
- From homoallenyl aldehydes to proton sponges
- Homoallenylaldehydes in synthesis of new sulfur heterocycles
- New caged %22proton sponges%22
- New Heterocycles by Allene Synthon
- Substituted Diazatetracyclo[4.4.0.13,10.15,8]dodecanes as Stable Caged Proton Sponges
- Substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles
- Allenyloxime - A New Versatile Precursor for the Synthesis of Heterocycles
- Novel Multicomponent Domino Approach to 2,5-Bifunctionalized Five-Membered Cyclic Nitrones
- Aplications of Caged-Designed Proton Sponges in Base-Catalyzed Transformations
- Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies
- Combined Intra-Intermolecular Criss-Cross Cycloaddition Reactions Leading to Perfluoroalkylated Fused Tricyclic Nitrogen Heterocycles
- Combined Intra-intermolecular Criss-cross Cycloaddition Reactions Leading to Perfluoroalkylated Fused Tricyclic Nitrogen Heterocycles
- Homoallenyl aldehyde as a synthon for useful transformations
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| is http://linked.open...vavai/cep/projekt
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