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  • Disruption of retinoid transport, metabolism and signaling by environmental pollutants. - a review. Although the assessment of circulatory levels of retinoids has become a widely used biomarker of exposure to environmental pollutants, the adverse effects caused by imbalance of the retinoid metabolism and signaling in wildlife are not known in detail. Retinoids play an important role in controlling such vital processes as morphogenesis, development, reproduction or apoptosis. Unlike other signaling molecules, retinoids are not strictly endogenous but they are derived from dietary sources of vitamin A or its precursors and thus they are sometimes referred to as dietary hormones. Some environmental pollutants that affect embryogenesis, immunity or epithelial functions were also shown to interfere with retinoid metabolism and signaling in animals. This suggests that at least some of their toxic effects may be associated with interaction with the retinoid metabolism, transport or signal transduction.
  • Disruption of retinoid transport, metabolism and signaling by environmental pollutants. - a review. Although the assessment of circulatory levels of retinoids has become a widely used biomarker of exposure to environmental pollutants, the adverse effects caused by imbalance of the retinoid metabolism and signaling in wildlife are not known in detail. Retinoids play an important role in controlling such vital processes as morphogenesis, development, reproduction or apoptosis. Unlike other signaling molecules, retinoids are not strictly endogenous but they are derived from dietary sources of vitamin A or its precursors and thus they are sometimes referred to as dietary hormones. Some environmental pollutants that affect embryogenesis, immunity or epithelial functions were also shown to interfere with retinoid metabolism and signaling in animals. This suggests that at least some of their toxic effects may be associated with interaction with the retinoid metabolism, transport or signal transduction. (en)
Title
  • Disruption of retinoid transport, metabolism and signaling by environmental pollutants
  • Disruption of retinoid transport, metabolism and signaling by environmental pollutants (en)
skos:prefLabel
  • Disruption of retinoid transport, metabolism and signaling by environmental pollutants
  • Disruption of retinoid transport, metabolism and signaling by environmental pollutants (en)
skos:notation
  • RIV/00216224:14310/08:00025288!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP525/05/P160), S, Z(MSM0021622412), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 363841
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/08:00025288
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • vitamin A; all-trans retinoic acid; pesticide; TCDD; polychlorinated biphenyls; retinoids (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [FBD50A67F40E]
http://linked.open...i/riv/nazevZdroje
  • Environment International
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 34
http://linked.open...iv/tvurceVysledku
  • Hilscherová, Klára
  • Novák, Jiří
  • Beníšek, Martin
http://linked.open...ain/vavai/riv/wos
  • 000259162000018
http://linked.open...n/vavai/riv/zamer
issn
  • 0160-4120
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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