About: A case-control study of the relationship between 13 candidate genes and ADHD

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). (en)
Title	A case-control study of the relationship between 13 candidate genes and ADHD A case-control study of the relationship between 13 candidate genes and ADHD (en)
skos:prefLabel	A case-control study of the relationship between 13 candidate genes and ADHD A case-control study of the relationship between 13 candidate genes and ADHD (en)
skos:notation	RIV/00216224:14310/06:00017436!RIV10-MZ0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8137), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pitelová, Renáta Šerý, Omar Drtílková, Ivana Lochman, Jan Mikeš, Vladimír Theiner, Pavel Štaif, Radim
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	463425
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00017436
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ADHD; polymorphism; DAT1; DRD2; COMT; MAOB; ACE; ANG; CCR5; BDNF; MU; IL-2; IL-6; TNF; M235T (en)
http://linked.open.../riv/klicoveSlovo	CCR5 BDNF IL-6 ADHD MU polymorphism MAOB IL-2 ACE M235T TNF COMT DAT1 DRD2 ANG
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3ED23D33EE6E]
http://linked.open...i/riv/nazevZdroje	American Journal of Medical Genetics
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular causes of dispositions to alcoholism.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	141B
http://linked.open...iv/tvurceVysledku	Drtílková, Ivana Šerý, Omar Lochman, Jan Mikeš, Vladimír Theiner, Pavel Štaif, Radim Pitelová, Renáta
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1552-4841
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	A case-control study of the relationship between 13 candidate genes and ADHD A case-control study of the relationship between 13 candidate genes and ADHD

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