About: Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although novel therapeutic strategies have prolonged survival of patients, the disease remains difficult to treat with a high risk of relapse. The failure of therapy is thought to be associated with a persistent population of the so-called MM stem cells or myeloma initiating cells (MIC) that exhibit tumour-initiating potential, self-renewal and resistance to chemotherapy. However, the population responsible for the origin and sustainability of tumour mass has not been clearly characterized so far. This review summarizes current myeloma stem cell concepts and suggests that high phenotypic and intra-clonal heterogeneity, together with plasticity potential of MM might be other contributing factors explaining discrepancies among particular concepts and contributing to the treatment failure. Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although novel therapeutic strategies have prolonged survival of patients, the disease remains difficult to treat with a high risk of relapse. The failure of therapy is thought to be associated with a persistent population of the so-called MM stem cells or myeloma initiating cells (MIC) that exhibit tumour-initiating potential, self-renewal and resistance to chemotherapy. However, the population responsible for the origin and sustainability of tumour mass has not been clearly characterized so far. This review summarizes current myeloma stem cell concepts and suggests that high phenotypic and intra-clonal heterogeneity, together with plasticity potential of MM might be other contributing factors explaining discrepancies among particular concepts and contributing to the treatment failure. (en)
Title	Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma (en)
skos:prefLabel	Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma (en)
skos:notation	RIV/00216224:14110/13:00065642!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1395), P(NT11154), P(NT13190)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Okubote, Samuel Adeyinka Šváchová, Hana Hájek, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	90303
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065642
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Malignant plasma cells; Multiple myeloma; Myeloma stem cells; Plasticity; Precursor B cells (en)
http://linked.open.../riv/klicoveSlovo	Malignant plasma cells Precursor B cells Myeloma stem cells Plasticity Multiple myeloma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D6B803F9FDC7]
http://linked.open...i/riv/nazevZdroje	BRITISH JOURNAL OF HAEMATOLOGY
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	163
http://linked.open...iv/tvurceVysledku	Hájek, Roman Šváchová, Hana Okubote, Samuel Adeyinka
http://linked.open...ain/vavai/riv/wos	000326807400003
issn	0007-1048
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/bjh.12563
http://localhost/t...ganizacniJednotka	14110

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