About: Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma (MM) is a malignancy of plasma cells (PCs) which accumulate in the bone marrow (BM), thus, leading to anemia, bone lesions, hypercalcemia, renal impairment and immune dysfunction. T regulatory (Treg) cells maintain immune homeostasis in healthy individuals by patrolling unwanted immune responses. Whereas in cancer patients, these cells are uncontrollably expanded, thereby, inhibiting the host anti-tumor responses. Majorly this work is focused to understand the role of Treg cells, including CD4 Treg cells and CD8 Treg cells in rendering the immune impairments in MM patients. This study clearly showed that both CD4 and CD8 Treg cells were functionally suppressive and increased in MM patients. These findings were confirmed by using different methods, including flow cytometry, functional and molecular studies (RT-PCR and western blot). Multiple myeloma (MM) is a malignancy of plasma cells (PCs) which accumulate in the bone marrow (BM), thus, leading to anemia, bone lesions, hypercalcemia, renal impairment and immune dysfunction. T regulatory (Treg) cells maintain immune homeostasis in healthy individuals by patrolling unwanted immune responses. Whereas in cancer patients, these cells are uncontrollably expanded, thereby, inhibiting the host anti-tumor responses. Majorly this work is focused to understand the role of Treg cells, including CD4 Treg cells and CD8 Treg cells in rendering the immune impairments in MM patients. This study clearly showed that both CD4 and CD8 Treg cells were functionally suppressive and increased in MM patients. These findings were confirmed by using different methods, including flow cytometry, functional and molecular studies (RT-PCR and western blot). (en)
Title	Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma (en)
skos:prefLabel	Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma (en)
skos:notation	RIV/00216224:14110/13:00065582!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(NT11154), P(NT13190)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hájek, Roman Muthu Raja, Karthick Raja
http://linked.open.../riv/druhVysledku	B - Odborná kniha
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	63487
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065582
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PROGNOSIS; Dexamethasone; T regulatory cells; Thalidomide; Immune Suppression; Multiple Myeloma; FOXP3; Cyclophosphamide; Lénalidomide; monoclonal protein (en)
http://linked.open.../riv/klicoveSlovo	Dexamethasone FOXP3 Immune Suppression Lénalidomide PROGNOSIS monoclonal protein Cyclophosphamide Thalidomide Multiple Myeloma T regulatory cells
http://linked.open...ontrolniKodProRIV	[EDC23B3C8526]
http://linked.open...i/riv/mistoVydani	Saarbrücken
http://linked.open...vEdiceCisloSvazku	Neuveden
http://linked.open...i/riv/nazevZdroje	Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	160 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Hájek, Roman Muthu Raja, Karthick Raja
number of pages	160 (xsd:int)
http://purl.org/ne...btex#hasPublisher	LAP Lambert Academic Publishing
https://schema.org/isbn	9783659369148
http://localhost/t...ganizacniJednotka	14110

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