About: Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and enhance immune dysfunction. In this study, we aimed to prove the presence of functionally suppressive Treg cells expressing CD8 phenotype (CD8 Treg cells) in MM. To the best of our knowledge, this has not been reported previously in MM. METHODS: We analyzed CD8 Treg cells and their transcription factor FoxP3 from 64 newly diagnosed MM patients using flow cytometry and real time-polymerase chain reaction (RT-PCR). RNA profile of cytokines in CD8 Treg cells was also assessed using RT-PCR. CD8 Treg cells from 5 MM patients and 5 healthy donors were functionally evaluated using proliferation assays. RESULTS: CD8 Treg cells (CD8+CD25hi+) were significantly elevated in MM patients (P<0.0001), and their transcription factor FoxP3 expression was also higher in MM (P<0. Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and enhance immune dysfunction. In this study, we aimed to prove the presence of functionally suppressive Treg cells expressing CD8 phenotype (CD8 Treg cells) in MM. To the best of our knowledge, this has not been reported previously in MM. METHODS: We analyzed CD8 Treg cells and their transcription factor FoxP3 from 64 newly diagnosed MM patients using flow cytometry and real time-polymerase chain reaction (RT-PCR). RNA profile of cytokines in CD8 Treg cells was also assessed using RT-PCR. CD8 Treg cells from 5 MM patients and 5 healthy donors were functionally evaluated using proliferation assays. RESULTS: CD8 Treg cells (CD8+CD25hi+) were significantly elevated in MM patients (P<0.0001), and their transcription factor FoxP3 expression was also higher in MM (P<0. (en)
Title	Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment (en)
skos:prefLabel	Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment (en)
skos:notation	RIV/00216224:14110/12:00057824!RIV13-GA0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(NT11154), P(NT12130), P(NT12425), P(NT13190), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Říhová, Lucie Hájek, Roman Muthu Raja, Karthick Raja Všianská, Pavla Héžová, Renata Kubiczková, Lenka Piskáček, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	137394
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00057824
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple myeloma; CD4 regulatory T cells; suppressive Treg cells (en)
http://linked.open.../riv/klicoveSlovo	Multiple myeloma CD4 regulatory T cells suppressive Treg cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DC935BE1F09D]
http://linked.open...i/riv/nazevZdroje	Public Library of Science one
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of B cell lineage mitotic disruptions in multiple myeloma Standardized flow cytometry as a toll for fast and sensitive diagnostics in hematology – implementation of the Euroflow protocols in Czech Republic Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma Complex analysis of importance and pathogenesis of extramedullary relapse in patients with multiple myeloma
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Hájek, Roman Pour, Luděk Říhová, Lucie Muthu Raja, Karthick Raja Všianská, Pavla Héžová, Renata Kubiczková, Lenka Piskáček, Martin
http://linked.open...ain/vavai/riv/wos	000311234600041
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	1932-6203
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0049446
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment

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