About: Medicinal applications of perfluoroalkylated chain-containing compounds

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.4155/FMC.14.53
Description	Compounds with polyfluorinated molecular fragments possess unique properties associated with the presence of a large number of fluorine atoms that affect lipophilicity and conformational rigidity of the parent molecule along with other effects. The aim of this review is to provide an overview of synthesized compounds possessing perfluoroalkylated or polyfluorinated chains that have been tested for bioactivity or as potential drug candidates for the treatment of various diseases. As far as the length of the perfluoroalkylated chain is concerned the focus is centered on the compound bearing perfluoroethyl or tetrafluoroethyl as well as longer chains. The perfluoroalkylated compounds discussed are classified according to their biological activity. Compounds with polyfluorinated molecular fragments possess unique properties associated with the presence of a large number of fluorine atoms that affect lipophilicity and conformational rigidity of the parent molecule along with other effects. The aim of this review is to provide an overview of synthesized compounds possessing perfluoroalkylated or polyfluorinated chains that have been tested for bioactivity or as potential drug candidates for the treatment of various diseases. As far as the length of the perfluoroalkylated chain is concerned the focus is centered on the compound bearing perfluoroethyl or tetrafluoroethyl as well as longer chains. The perfluoroalkylated compounds discussed are classified according to their biological activity. (en)
Title	Medicinal applications of perfluoroalkylated chain-containing compounds Medicinal applications of perfluoroalkylated chain-containing compounds (en)
skos:prefLabel	Medicinal applications of perfluoroalkylated chain-containing compounds Medicinal applications of perfluoroalkylated chain-containing compounds (en)
skos:notation	RIV/00216208:11310/14:10285969!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA13-15915S)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Smrček, Stanislav Kotora, Martin Štěpánek, Ondřej Prchalová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	28214
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10285969
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human neutrophil elastase; active pure antiestrogens; potassium channel openers; human cytomegalovirus protease; histone deacetylase inhibitors; progesterone-receptor antagonists; clostridium-histolyticum collagenase; carbonic-anhydrase inhibitors (en)
http://linked.open.../riv/klicoveSlovo	histone deacetylase inhibitors active pure antiestrogens carbonic-anhydrase inhibitors clostridium-histolyticum collagenase human cytomegalovirus protease human neutrophil elastase potassium channel openers progesterone-receptor antagonists
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DA11CA3E9137]
http://linked.open...i/riv/nazevZdroje	Future Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of zirconocene-based methods for sesquiterpenoids synthesis
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Kotora, Martin Štěpánek, Ondřej Prchalová, Eva Smrček, Stanislav
http://linked.open...ain/vavai/riv/wos	000346694000012
issn	1756-8919
number of pages	29 (xsd:int)
http://bibframe.org/vocab/doi	10.4155/FMC.14.53
http://localhost/t...ganizacniJednotka	11310

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