About: Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo

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About: Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S1756464614002254
Description	Green tea represents a favourite beverage and green tea extracts are popular components of dietary supplements.The aim of present in vivo study was to report on the effect of defined green tea extract (Polyphenon) in various dosage schemes on drug-metabolizing enzymes in mice. The specific activities and expressions of a panel of drug-metabolizing enzymes (totally 16) were tested in liver and small intestine. Nine enzymes were significantly altered by Polyphenon treatment.The intestinal enzymes were more affected than the hepatic ones. The effects were mostly dose-dependent but short-term treatment had more pronounced impact than the long-term administration. Based on the results, normal consumption of green tea seems to be safe but extremely high doses of green tea extracts in dietary supplements could influence drugs metabolism and efficacy. Green tea represents a favourite beverage and green tea extracts are popular components of dietary supplements.The aim of present in vivo study was to report on the effect of defined green tea extract (Polyphenon) in various dosage schemes on drug-metabolizing enzymes in mice. The specific activities and expressions of a panel of drug-metabolizing enzymes (totally 16) were tested in liver and small intestine. Nine enzymes were significantly altered by Polyphenon treatment.The intestinal enzymes were more affected than the hepatic ones. The effects were mostly dose-dependent but short-term treatment had more pronounced impact than the long-term administration. Based on the results, normal consumption of green tea seems to be safe but extremely high doses of green tea extracts in dietary supplements could influence drugs metabolism and efficacy. (en)
Title	Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo (en)
skos:prefLabel	Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo (en)
skos:notation	RIV/00216208:11160/14:10281589!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0004), P(EE2.3.30.0022), P(GBP303/12/G163)
http://linked.open...iv/cisloPeriodika	September
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Skorkovská, Jana Matoušková, Petra Boušová, Iva Skálová, Lenka Hanušová, Veronika Szotáková, Barbora Martin, Jan Bártíková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	13217
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281589
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Inhibition; Induction; Biotransformation; Flavonoids; Drug interaction; Dietary supplement (en)
http://linked.open.../riv/klicoveSlovo	Drug interaction Inhibition Induction Flavonoids Biotransformation Dietary supplement
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B28B9CF66CE3]
http://linked.open...i/riv/nazevZdroje	Journal of Functional Foods
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of drug-dietary supplements interactions and nutrigenetics POST-UP Support of establishment, development, and mobility of quality research teams at the Charles University
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Boušová, Iva Anzenbacher, Pavel Anzenbacherová, Eva Lišková, Barbora Hanušová, Veronika Skálová, Lenka Szotáková, Barbora Martin, Jan Matoušková, Petra Bártíková, Hana Tománková, Veronika Skorkovská, Jana
http://linked.open...ain/vavai/riv/wos	000342034200035
issn	1756-4646
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jff.2014.06.026
http://localhost/t...ganizacniJednotka	11160

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