About: Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice

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About: Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In previous papers (1,2) we demonstrated that procaine hydrochloride may increase the therapeutic index of cisplatin by an improvement of its antitumor activity and a reduction of its nephrotoxicity. In the present study we investigated the relationship between the antitumor activity obtained by cisplatin associated with procaine hydrochloride and the relative time of administration of these two agents. When procaine hydrochloride (40 mg/Kg body wt) was administered 30 or 120 minutes before cisplatin (16 mg/kg) diluted in normal saline (i.e. clinical condition) it increased, although not significantly, its percent increase in life span (%ILS) and cure rate (%ILS: +292 and +217 vs +150; cute rate: 46.2% and 42.3% vs 23%, respectively), compared to cisplatin alone treatment. These results became statistically significant when procaine hydrochloride was given either simultaneously with cisplatin ol 30 and 120 minutes thereafter (%ILS: >400 vs +150; cure rate: 65.4% 73.1% and 68% vs 23%, respectively). In previous papers (1,2) we demonstrated that procaine hydrochloride may increase the therapeutic index of cisplatin by an improvement of its antitumor activity and a reduction of its nephrotoxicity. In the present study we investigated the relationship between the antitumor activity obtained by cisplatin associated with procaine hydrochloride and the relative time of administration of these two agents. When procaine hydrochloride (40 mg/Kg body wt) was administered 30 or 120 minutes before cisplatin (16 mg/kg) diluted in normal saline (i.e. clinical condition) it increased, although not significantly, its percent increase in life span (%ILS) and cure rate (%ILS: +292 and +217 vs +150; cute rate: 46.2% and 42.3% vs 23%, respectively), compared to cisplatin alone treatment. These results became statistically significant when procaine hydrochloride was given either simultaneously with cisplatin ol 30 and 120 minutes thereafter (%ILS: >400 vs +150; cure rate: 65.4% 73.1% and 68% vs 23%, respectively). (en)
Title	Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice (en)
skos:prefLabel	Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice (en)
skos:notation	RIV/00216208:11120/01:00003667!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5039906), Z(MSM 111200001)
http://linked.open...iv/cisloPeriodika	1A
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mandys, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	698826
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003667
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cisplatin; procaine; antitumor activity (en)
http://linked.open.../riv/klicoveSlovo	cisplatin antitumor activity procaine
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[2E25026399A1]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Mandys, Václav Viale, M.
http://linked.open...ain/vavai/riv/wos	000167875900072
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111200001
issn	0250-7005
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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