About: Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation     Goto   Sponge   Distinct   Permalink

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Description
  • OBJECTIVES: Weight gain has been reported in patients with Parkinson's disease (PD) treated with deep brain stimulation of the subthalamic nucleus (STN-DBS). To evaluate the influence of STN-DBS on weight changes, we studied food-related hormones. DESIGN: Anthropometric parameters and food-related hormones (leptin, adiponectin, resistin, ghrelin, cortisol, insulin, and thyroid stimulating hormone) were measured in 27 patients with STN-DBS during a 12 month period following electrode implantation. RESULTS: Besides marked motor improvements on STN-DBS, PD patients significantly gained weight. The mean weight gain at 12 months was 5.2 +/-(SD)5.8 kg. A significant decrease in cortisol levels compared to baseline appeared at month 2 and persisted at 12 months (p<0.01, corrected), with no significant changes in other hormones tested. CONCLUSIONS: Changes in peripheral food-related hormones do not appear to cause weight gain in PD patients. Direct effects of STN-DBS on hypothalamic catabolic/anabolic peptide balance remain hypothetical and necessitate further elucidation.
  • OBJECTIVES: Weight gain has been reported in patients with Parkinson's disease (PD) treated with deep brain stimulation of the subthalamic nucleus (STN-DBS). To evaluate the influence of STN-DBS on weight changes, we studied food-related hormones. DESIGN: Anthropometric parameters and food-related hormones (leptin, adiponectin, resistin, ghrelin, cortisol, insulin, and thyroid stimulating hormone) were measured in 27 patients with STN-DBS during a 12 month period following electrode implantation. RESULTS: Besides marked motor improvements on STN-DBS, PD patients significantly gained weight. The mean weight gain at 12 months was 5.2 +/-(SD)5.8 kg. A significant decrease in cortisol levels compared to baseline appeared at month 2 and persisted at 12 months (p<0.01, corrected), with no significant changes in other hormones tested. CONCLUSIONS: Changes in peripheral food-related hormones do not appear to cause weight gain in PD patients. Direct effects of STN-DBS on hypothalamic catabolic/anabolic peptide balance remain hypothetical and necessitate further elucidation. (en)
Title
  • Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation
  • Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation (en)
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  • Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation
  • Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation (en)
skos:notation
  • RIV/00216208:11110/11:8736!RIV12-MZ0-11110___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N, P(GA309/09/1145), P(NT11331), Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 202709
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/11:8736
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Deep brain stimulation; subthalamic nucleus; weight gain; leptin; cortisol; deep brain-stimulation; body-weight; ghrelin levels; leptin; adiponectin; surgery; obesity; oxidation; decrease; increase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SE - Švédské království
http://linked.open...ontrolniKodProRIV
  • [188B7E464B3B]
http://linked.open...i/riv/nazevZdroje
  • Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 32
http://linked.open...iv/tvurceVysledku
  • Haluzík, Martin
  • Růžička, Evžen
  • Nováková, Lucie
  • Urgošík, Dušan
  • Růžička, Filip
  • Jech, Robert
http://linked.open...ain/vavai/riv/wos
  • 000295440000013
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-780X
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  • 11110
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