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rdf:type
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Description
| - Using immunoprecipitation and Western blots performed on lysates made of melanoma cells derived from patients with clinical stage II/III and employing specific anti-STAT 1 PS 727/PY 701 immunoprobes, we show that STAT 1 activation response induced by IFN-alfa/-gamma is significantly impaired. In average, three quarters of patients were lacking phosphorylation at S 727. STAT 1 PY 701 was not inducible by IFN-alfa in 63% and by IFN-gamma in 34% of samples However, these STAT 1 activation defects showed no correlation with the disease outcome and immunotherapy response as indicated by progression-free survival profiles in patients treated with IFN-alfa2b.
- Using immunoprecipitation and Western blots performed on lysates made of melanoma cells derived from patients with clinical stage II/III and employing specific anti-STAT 1 PS 727/PY 701 immunoprobes, we show that STAT 1 activation response induced by IFN-alfa/-gamma is significantly impaired. In average, three quarters of patients were lacking phosphorylation at S 727. STAT 1 PY 701 was not inducible by IFN-alfa in 63% and by IFN-gamma in 34% of samples However, these STAT 1 activation defects showed no correlation with the disease outcome and immunotherapy response as indicated by progression-free survival profiles in patients treated with IFN-alfa2b. (en)
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Title
| - Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients
- Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients (en)
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skos:prefLabel
| - Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients
- Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients (en)
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skos:notation
| - RIV/00209805:_____/03:00008209!RIV/2004/GA0/L26004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA301/00/0564), P(NC7139), Z(MZ00020980501)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00209805:_____/03:00008209
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - STAT 1;malignant melanoma;signal transduction;interferons (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Boudný, Vladimír
- Kovařík, Jan
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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