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rdf:type
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Description
| - p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies
- p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies (en)
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Title
| - Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia
- Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia (en)
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skos:prefLabel
| - Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia
- Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia (en)
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skos:notation
| - RIV/00064173:_____/08:00001288!RIV13-MZ0-00064173
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00064173:_____/08:00001288
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - yeast; protein; modifier; radiation; expression; phosphatase; mdm2; mutation; isoforms; functional assay (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kozák, Tomáš
- Špaček, Martin
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.leukres.2007.06.022
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is http://linked.open...avai/riv/vysledek
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