About: Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We compared the binding affinities of the shortened and full-length insulin analogs [NMeHisB26]-DTI-NH2 and [NMeAlaB26]-DTI-NH2 with substitutions at position B26. We found that our shortened analogs, have different modes of interaction with the insulin receptor compared to natural insulin. We compared the binding affinities of the shortened and full-length insulin analogs [NMeHisB26]-DTI-NH2 and [NMeAlaB26]-DTI-NH2 with substitutions at position B26. We found that our shortened analogs, have different modes of interaction with the insulin receptor compared to natural insulin. (en) Zkrácená analoga inzulinu , [NMeHisB26]-DTI-NH2 and [NMeAlaB26]-DTI-NH2 mají v porovnání s normálním inzulinem odlišný způsob interakce s inzulinovým receptorem. Přes vysokou vazebnou aktivitu je metabolický účinek snížen. (cs)
Title	Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity (en) Inzulinová analoga s modifikací v pozici B6. Divergence vazebné afinity a biologické aktivity. (cs)
skos:prefLabel	Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity (en) Inzulinová analoga s modifikací v pozici B6. Divergence vazebné afinity a biologické aktivity. (cs)
skos:notation	RIV/00023001:_____/08:00001758!RIV09-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KJB400550702), P(LC06077), Z(AV0Z40550506), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kazdová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	372646
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/08:00001758
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	insulin; analog; binding affinity; biological activity; B26; N-methylation; glukose; adipocytes. (en)
http://linked.open.../riv/klicoveSlovo	analog insulin binding affinity N-methylation biological activity B26 adipocytes. glukose
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[98B926CFCE64]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Chemical Genetics New full-length analogs of human insulin with modifications in positions B24-B26.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Buděšínský, M. Kazdová, Ludmila Šanda, M. Žáková, L. Hančlová, I. Jiráček, J. Protivínská, E.
http://linked.open...ain/vavai/riv/wos	000256043200020
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0006-2960
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity

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