. "A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)NCI" . "C0593507"^^ . "C561"^^ . "ibuprofenPTNCI-GLOSSCDR0000613511" . "MotrinBRNCI" . "IBUPROFENPTFDAWK2XYI10QM" . "Ibuprofen"^^ . "p-Isobutylhydratropic AcidSNNCI" . "FDA"^^ . "256857"^^ . "IbuprofenPTNCI" . "IbuprofenPTDCP00803" . "40475"^^ . "(.+ -.)-p-Isobutylhydratropic acidSYDTPNSC0256857" . "CHEBI:5855"^^ . "Ibuprofen"^^ . _:b682119 . _:b682119 . . . "Pharmacologic Substance"^^ . "AdvilPTNCI-GLOSSCDR0000613724" . "Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-SNNCI" . _:b682119 . "Organic Chemical"^^ . "40475"^^ . "15687-27-1"^^ . "MotrinPTNCI-GLOSSCDR0000613512" . . "WK2XYI10QM"^^ . _:b682119 . "p-Isobutylhydratropic acidSYDTPNSC0256857" . "A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).NCI-GLOSS" . "A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.MSH2002_06_01" . "MotrinSYDTPNSC0256857" . "Ibuprofen"^^ . "C13H18O2"^^ .