This HTML5 document contains 341 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/pubchem-compound/
dctermshttp://purl.org/dc/terms/
n25http://linked.opendata.cz/resource/AHFS/
n16http://linked.opendata.cz/resource/mesh/concept/
foafhttp://xmlns.com/foaf/0.1/
n22http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/pubchem-substance/
n5http://linked.opendata.cz/resource/drugbank/company/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/kegg-drug/
n6http://linked.opendata.cz/resource/drugbank/dosage/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/iuphar/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/drugbank/
n18http://www.drugs.com/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/guide-to-pharmacology/
n28http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n24http://www.rxlist.com/cgi/generic/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/chemspider/
n27http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n14http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/chebi/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n29http://linked.opendata.cz/resource/drugbank/medicinal-product/
n15http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
n31http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/wikipedia/
xsdhhttp://www.w3.org/2001/XMLSchema#
n30http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/pharmgkb/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00898/identifier/kegg-compound/
n20http://linked.opendata.cz/resource/atc/
n19http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00898
rdf:type
n3:Drug
n3:description
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem]
n3:dosage
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n3:generalReferences
# Snyder R, Kalf GF: A perspective on benzene leukemogenesis. Crit Rev Toxicol. 1994;24(3):177-209. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7945890 # Chastain G: Alcohol, neurotransmitter systems, and behavior. J Gen Psychol. 2006 Oct;133(4):329-35. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17128954 # McDonnell G, Russell AD: Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9880479 # Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA: American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol. 2002;40(4):415-46. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12216995 # Hingson R, Winter M: Epidemiology and consequences of drinking and driving. Alcohol Res Health. 2003;27(1):63-78. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15301401
n3:group
approved
n3:indication
For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.
n3:manufacturer
n5:271B5A46-363D-11E5-9242-09173F13E4C5
owl:sameAs
n27:DB00898 n28:DB00898
dcterms:title
Ethanol
adms:identifier
n8:2299 n9:682 n10:DB00898 n11:D00068 n12:2299 n13:C00469 n14:16236 n22:46506969 n23:702 n30:PA448073 n31:Ethanol
n3:mechanismOfAction
Ethanol affects the brain’s neurons in several ways. It alters their membranes as well as their ion channels, enzymes, and receptors. Alcohol also binds directly to the receptors for acetylcholine, serotonin, GABA, and the NMDA receptors for glutamate. The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). It also inhibits NMDA receptor functioning. In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.
n3:packager
n5:271B5A45-363D-11E5-9242-09173F13E4C5 n5:271B5A43-363D-11E5-9242-09173F13E4C5 n5:271B5A44-363D-11E5-9242-09173F13E4C5 n5:271B5A41-363D-11E5-9242-09173F13E4C5 n5:271B5A42-363D-11E5-9242-09173F13E4C5 n5:271B5A3E-363D-11E5-9242-09173F13E4C5 n5:271B5A3F-363D-11E5-9242-09173F13E4C5 n5:271B5A3C-363D-11E5-9242-09173F13E4C5 n5:271B5A3D-363D-11E5-9242-09173F13E4C5 n5:271B5A40-363D-11E5-9242-09173F13E4C5
n3:synonym
Dehydrated ethanol EtOH Alkohol Aethanol Alcohol Ethanol Ethyl Alcohol Etanol Aethylalkohol Spiritus vini Alcohol etílico [CH2Me(OH)] Hydroxyethane [OEtH] Alcool éthylique 1-Hydroxyethane Methylcarbinol C2H5OH
n3:toxicity
Oral, rat LD<sub>50</sub>: 5628 mg/kg. Symptoms and effects of overdose include nausea, vomiting, CNS depression, acute respiratory failure or death and with chronic use, severe health problems, such as liver and brain damage.
n19:hasAHFSCode
n25:84-04-92 n25:92-00-00 n25:92-02-00%2A
n3:synthesisReference
William S. Hedrick, "Process for ethanol production from cellulosic materials." U.S. Patent US4650689, issued June, 1917.
n15:hasConcept
n16:M0000653
foaf:page
n18:alcohol.html n24:dhydalco.htm
n3:IUPAC-Name
n4:271B5B41-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5B47-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5B46-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5B43-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5B44-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5B45-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5B3F-363D-11E5-9242-09173F13E4C5 n4:271B5B57-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5B40-363D-11E5-9242-09173F13E4C5 n4:271B5B3D-363D-11E5-9242-09173F13E4C5 n4:271B5B5A-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5B3E-363D-11E5-9242-09173F13E4C5
n3:pKa
n4:271B5B5B-363D-11E5-9242-09173F13E4C5
n19:hasATCCode
n20:D08AX08 n20:V03AB16 n20:V03AZ01
n3:H-Bond-Acceptor-Count
n4:271B5B4D-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5B4E-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5B48-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5B49-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5B4B-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5B4A-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5B4C-363D-11E5-9242-09173F13E4C5
n3:absorption
Rapidly absorbed.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
64-17-5
n3:category
n3:containedIn
n29:271B5A49-363D-11E5-9242-09173F13E4C5 n29:271B5A47-363D-11E5-9242-09173F13E4C5 n29:271B5A48-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B5B53-363D-11E5-9242-09173F13E4C5
n3:Boiling-Point
n4:271B5B59-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5B55-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B5B56-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B5B58-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5B52-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5B51-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5B54-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5B42-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5B4F-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5B50-363D-11E5-9242-09173F13E4C5