. . . . . . . "87%"@en . . . . . . . . . . . . . "Chlorhexidine"@en . . . . . . . . . . . . . . . . . " "@en . . . . . . . . " "@en . . . "Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms."@en . . . "Cloresidina"@en . . . . . . . . . . "N,N'-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide"@en . . . . . . "LD₅₀= 2g/kg (human, oral); LD₅₀= 3 g/kg (rat, oral); LD₅₀= 2.5 g/kg (mice, oral); LD₅₀= 21 mg/kg (male rat, IV); LD₅₀= 23 mg/kg (female rat, IV); LD₅₀= 25 mg/kg (male mice, IV); LD₅₀= 24 mg/kg (female mice, IV); LD₅₀= 1g/kg (rat, subcutaneous); LD₅₀= 637 mg/kg (male mice, subcutaneous); LD₅₀= 632 mg/kg (female mice, subcutaneous)"@en . . "Rose, F.L. and Swain, G.; US. Patent 2,684,924; July 27, 1954; assigned to Imperial Chemical Industries, Ltd."@en . . . . . . . "Bacteria"@en . . . . . . "Chlorhexidine"@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Chlorhexidinum"@en . . "Absorption of chlorhexidine from the gastrointestinal tract is very poor. Additionally, an in vivo study in 18 adult patients found no detectable plasma or urine chlorhexidine concentrations following insertion of four periodontal implants under clinical conditions."@en . . . "Chlorhexidin"@en . . . . . . "approved"@en . "1,1'-Hexamethylene bis(5-(P-chlorophenyl)biguanide)"@en . . "55-56-1"@en . . . "Excretion of chlorhexidine gluconate occurred primarily through the feces (~90%). Less than 1% of the chlorhexidine gluconate ingested by these subjects was excreted in the urine."@en . . . . . . . "# McBain AJ, Bartolo RG, Catrenich CE, Charbonneau D, Ledder RG, Gilbert P: Effects of a chlorhexidine gluconate-containing mouthwash on the vitality and antimicrobial susceptibility of in vitro oral bacterial ecosystems. Appl Environ Microbiol. 2003 Aug;69(8):4770-6. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/12902270"@en . . . . . . . . . . "Clorhexidina"@en . . . . "A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. [PubChem]"@en . . . . . "For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care."@en . . . .