. . . . . . . . . . . . . . . . . . "The mechanism of action of rimantadine is not fully understood. Rimantadine appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. Genetic studies suggest that a virus protein specified by the virion M2 gene plays an important role in the susceptibility of influenza A virus to inhibition by rimantadine."@en . . . . . " "@en . "For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults."@en . "SID29215455"@en . . "Human Influenza A Virus"@en . . "Rimantadine"@en . "Oral LD₅₀ in rats is 640 mg/kg. Overdoses of a related rug, amantadine, have been reported with adverse reactions consisting of agitation, hallucinations, cardiac arrhythmia and death."@en . "Well absorbed, with the tablet and syrup formulations being equally absorbed after oral administration."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "13392-28-4"@en . . . . . . "\"DrugSyn.org\":http://www.drugsyn.org/Rimantadine.htm"@en . . . . . . . . . "Following oral administration, rimantadine is extensively metabolized in the liver with less than 25% of the dose excreted in the urine as unchanged drug."@en . . "approved"@en . . "Approximately 40% over typical plasma concentrations."@en . . . "An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. [PubChem]"@en . . . . . . "Rimantadin"@en . "25 to 30 hours in young adults (22 to 44 years old). Approximately 32 hours in elderly (71 to 79 years old) and in patients with chronic liver disease. Approximately 13 to 38 hours in children (4 to 8 years old)."@en . . . "Rimantadine"@en . . . . . . .