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Namespace Prefixes

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Statements

Subject Item
n2:DB00102
rdf:type
n3:Drug
n3:description
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds
n3:dosage
n23:271B453F-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000212/WC500050140.pdf #Lexicomp [Internet]. Becaplermin. 2014 [cited 12 November 2014]. Available from: http://online.lexi.com.login.ezproxy.library.ualberta.ca/lco/action/doc/retrieve/docid/patch_f/6420#f_pharmacology-and-pharmacokinetics
n3:group
approved investigational
n3:indication
For topical treatment of skin ulcers (from diabetes)
owl:sameAs
n7:DB00102 n16:DB00102
dcterms:title
Becaplermin
adms:identifier
n5:PA164749511 n8:Becaplermin n14:DB00102 n17:P01127 n20:K01401
n3:mechanismOfAction
Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. PDGF receptors also contain many auto-phosphorylation sites, which serve to mediate binding of SH2 sites and subsequently signal corresponding pathways. There are five different isoforms of PDGF that activate through two different receptors (alpha and beta).
n3:packager
n22:271B453B-363D-11E5-9242-09173F13E4C5 n22:271B453C-363D-11E5-9242-09173F13E4C5 n22:271B4539-363D-11E5-9242-09173F13E4C5 n22:271B453A-363D-11E5-9242-09173F13E4C5 n22:271B4538-363D-11E5-9242-09173F13E4C5
n3:patent
n9:1340846
n3:synonym
Platelet-derived growth factor B chain precursor c-sis PDGF-2 PDGF B-chain Platelet-derived growth factor beta polypeptide
n10:hasAHFSCode
n11:84-16-00
n24:hasConcept
n25:M0195683
foaf:page
n19:becapler.htm n26:becaplermin.html
n3:Molecular-Formula
n12:271B4543-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n12:271B4542-363D-11E5-9242-09173F13E4C5
n10:hasATCCode
n15:D03AX06 n15:A01AD08
n3:absorption
very little systemic absorption. 15% of patients experienced complete healing within 8 weeks, while for 25% of patients, it was at 10 weeks.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
165101-51-9
n3:category
n3:containedIn
n21:271B453D-363D-11E5-9242-09173F13E4C5 n21:271B453E-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n12:271B4540-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n12:271B4541-363D-11E5-9242-09173F13E4C5