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Namespace Prefixes

PrefixIRI
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n9http://linked.opendata.cz/resource/drugbank/drug/DB00098/identifier/pharmgkb/

Statements

Subject Item
n2:DB00098
rdf:type
n3:Drug
n3:description
Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
n3:generalReferences
#American Society of Health System Pharmacists, Inc., DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995. Antithymocyte globulin; [updated 2013 Jan 18; cited 2014 Nov 11]; Available http://web.b.ebscohost.com.login.ezproxy.library.ualberta.ca/dynamed/detail?vid=7&sid=78010ea4-6f9c-4d5a-a7df-a148b3891321%40sessionmgr110&hid=123&bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d#db=dme&AN=356335
n3:group
approved
n3:halfLife
2-3 days, may increase after multiple doses administration
n3:indication
For prevention of renal transplant rejection
owl:sameAs
n7:DB00098 n13:DB00098
dcterms:title
Antithymocyte globulin
adms:identifier
n9:PA164743704 n12:DB00098
n3:mechanismOfAction
Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.
n3:packager
n5:271B450D-363D-11E5-9242-09173F13E4C5
n3:synonym
Thymoglobulin rabbit ATG rATG
n3:toxicity
Not known whether ATG (rabbit) distributes into human milk; however, other immunoglobulins are distributed into human milk.
n14:hasConcept
n15:M0001465
n3:absorption
T-cell depletion usually observed within 1 day after initiating therapy. Average 21.5 and 87 mcg/mL 4–8 hours post-infusion after first and last IV doses, respectively, when given for 7–11 days.
n3:affectedOrganism
Humans and other mammals
n3:category
n3:containedIn
n11:271B450E-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B450F-363D-11E5-9242-09173F13E4C5