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Namespace Prefixes

PrefixIRI
n10http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n21http://linked.opendata.cz/resource/AHFS/
foafhttp://xmlns.com/foaf/0.1/
n17http://linked.opendata.cz/resource/drugbank/company/
n8http://linked.opendata.cz/resource/mesh/concept/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00095/identifier/drugbank/
n14http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n15http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n20http://www.drugs.com/cdi/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/resource/drugbank/drug/DB00095/identifier/pharmgkb/
n6http://linked.opendata.cz/resource/drugbank/drug/DB00095/identifier/wikipedia/
n12http://linked.opendata.cz/resource/atc/
n11http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00095
rdf:type
n3:Drug
n3:description
Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
n3:generalReferences
# "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8943405 # Descamps V: [Efalizumab] Ann Dermatol Venereol. 2006 Aug-Sep;133(8-9 Pt 1):666-78. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17053736
n3:group
approved investigational
n3:halfLife
5 days
n3:indication
For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy.
owl:sameAs
n14:DB00095 n15:DB00095
dcterms:title
Efalizumab
adms:identifier
n6:Efalizumab n16:PA164748817 n19:DB00095
n3:mechanismOfAction
Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.
n3:packager
n17:271B44E8-363D-11E5-9242-09173F13E4C5
n3:synonym
Raptiva hu1124 anti alphaL integrin antiCD11 alpha
n11:hasAHFSCode
n21:84-92-00
n7:hasConcept
n8:M0447098
foaf:page
n10:raptiva.htm n20:efalizumab.html
n11:hasATCCode
n12:L04AA21
n3:absorption
Average efalizumab bioavailability following subcutaneous administration was estimated at 30 to 50%.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
214745-43-4
n3:category
n3:Melting-Point
n4:271B44E9-363D-11E5-9242-09173F13E4C5