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Namespace Prefixes

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Statements

Subject Item
n2:DB00087
rdf:type
n7:Drug
n7:description
Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.
n7:dosage
n17:271B4423-363D-11E5-9242-09173F13E4C5 n17:271B4420-363D-11E5-9242-09173F13E4C5 n17:271B4421-363D-11E5-9242-09173F13E4C5 n17:271B4422-363D-11E5-9242-09173F13E4C5
n7:generalReferences
# Hale G, Bright S, Chumbley G, Hoang T, Metcalf D, Munro AJ, Waldmann H: Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood. 1983 Oct;62(4):873-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6349718 # Riechmann L, Clark M, Waldmann H, Winter G: Reshaping human antibodies for therapy. Nature. 1988 Mar 24;332(6162):323-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3127726 # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=1BEY # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=1CE1 # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=8005
n7:group
approved investigational
n7:halfLife
~288 hrs
n7:indication
Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia.
owl:sameAs
n9:DB00087 n21:DB00087
dcterms:title
Alemtuzumab
adms:identifier
n6:PA164783958 n14:50419-357-03 n16:DB00087 n22:Alemtuzumab
n7:mechanismOfAction
Campath binds to the CD52 antigen present on most B and T lymphocytes. This binding leads to antibody-dependent lysis of leukemic cells.
n7:packager
n15:271B441D-363D-11E5-9242-09173F13E4C5 n15:271B441B-363D-11E5-9242-09173F13E4C5 n15:271B441C-363D-11E5-9242-09173F13E4C5 n15:271B441A-363D-11E5-9242-09173F13E4C5
n7:patent
n11:1339198
n7:volumeOfDistribution
* 0.18 L/kg
n3:hasAHFSCode
n4:10-00-00
foaf:page
n19:alemtuzumab.html n20:campath.htm
n7:Molecular-Formula
n10:271B4428-363D-11E5-9242-09173F13E4C5
n7:Molecular-Weight
n10:271B4427-363D-11E5-9242-09173F13E4C5
n3:hasATCCode
n13:L04AA34
n7:casRegistryNumber
216503-57-0
n7:containedIn
n12:271B441F-363D-11E5-9242-09173F13E4C5 n12:271B441E-363D-11E5-9242-09173F13E4C5
n7:Hydrophobicity
n10:271B4425-363D-11E5-9242-09173F13E4C5
n7:Isoelectric-Point
n10:271B4426-363D-11E5-9242-09173F13E4C5
n7:Melting-Point
n10:271B4424-363D-11E5-9242-09173F13E4C5