This HTML5 document contains 28 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n20http://linked.opendata.cz/resource/AHFS/
n15http://linked.opendata.cz/resource/mesh/concept/
n23http://linked.opendata.cz/resource/drugbank/company/
foafhttp://xmlns.com/foaf/0.1/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/drugbank/
n17http://bio2rdf.org/drugbank:
n11http://www.drugs.com/cons/
admshttp://www.w3.org/ns/adms#
n9http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n14http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n7http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/uniprotkb/
n16http://www.rxlist.com/cgi/generic2/
n5http://linked.opendata.cz/resource/drugbank/property/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/genbank/
xsdhhttp://www.w3.org/2001/XMLSchema#
n21http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/wikipedia/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/pharmgkb/
n22http://linked.opendata.cz/resource/atc/
n19http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00086
rdf:type
n3:Drug
n3:description
Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.
n3:group
approved
n3:indication
For the treatment of acute evolving transmural myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis or emolism and occlusion of arteriovenous cannulae
owl:sameAs
n9:DB00086 n17:DB00086
dcterms:title
Streptokinase
adms:identifier
n7:P00779 n12:K02986 n13:PA164754919 n18:DB00086 n21:Streptokinase
n3:mechanismOfAction
Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting cascade. Streptokinase forms a highly specific 1:1 enzymatic complex with plasminogen which converts inactive plasminogen molecules into active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins. This in turn leads to the degradation of blood clots.
n3:packager
n23:271B4415-363D-11E5-9242-09173F13E4C5
n3:synonym
Streptokinase C precursor
n19:hasAHFSCode
n20:20-12-20
n3:synthesisReference
Lawrence Isaac Galler, "Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy." U.S. Patent US6087332, issued July, 1997.
n14:hasConcept
n15:M0020580
foaf:page
n11:streptokinase-intravenous-intracoronary.html n16:streptokinase.htm
n3:Molecular-Formula
n5:271B4419-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B4418-363D-11E5-9242-09173F13E4C5
n19:hasATCCode
n22:B01AD01
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9002-01-1
n3:category
n3:Hydrophobicity
n5:271B4416-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n5:271B4417-363D-11E5-9242-09173F13E4C5