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Namespace Prefixes

PrefixIRI
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n6http://linked.opendata.cz/resource/drugbank/drug/DB00085/identifier/genbank/
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n18http://www.drugs.com/cdi/
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n14http://www.rxlist.com/cgi/generic2/
xsdhhttp://www.w3.org/2001/XMLSchema#
n23http://linked.opendata.cz/resource/drugbank/drug/DB00085/identifier/kegg-drug/

Statements

Subject Item
n2:DB00085
rdf:type
n3:Drug
n3:description
Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa™ and Viokace™.
n3:dosage
n15:271B440A-363D-11E5-9242-09173F13E4C5 n15:271B440B-363D-11E5-9242-09173F13E4C5 n15:271B440C-363D-11E5-9242-09173F13E4C5 n15:271B440D-363D-11E5-9242-09173F13E4C5 n15:271B440E-363D-11E5-9242-09173F13E4C5 n15:271B440F-363D-11E5-9242-09173F13E4C5 n15:271B4410-363D-11E5-9242-09173F13E4C5 n15:271B4402-363D-11E5-9242-09173F13E4C5 n15:271B4403-363D-11E5-9242-09173F13E4C5 n15:271B4404-363D-11E5-9242-09173F13E4C5 n15:271B4405-363D-11E5-9242-09173F13E4C5 n15:271B4406-363D-11E5-9242-09173F13E4C5 n15:271B4407-363D-11E5-9242-09173F13E4C5 n15:271B4408-363D-11E5-9242-09173F13E4C5 n15:271B4409-363D-11E5-9242-09173F13E4C5 n15:271B43FA-363D-11E5-9242-09173F13E4C5 n15:271B43FB-363D-11E5-9242-09173F13E4C5 n15:271B43FC-363D-11E5-9242-09173F13E4C5 n15:271B43FD-363D-11E5-9242-09173F13E4C5 n15:271B43FE-363D-11E5-9242-09173F13E4C5 n15:271B43FF-363D-11E5-9242-09173F13E4C5 n15:271B4400-363D-11E5-9242-09173F13E4C5 n15:271B4401-363D-11E5-9242-09173F13E4C5 n15:271B43F5-363D-11E5-9242-09173F13E4C5 n15:271B43F6-363D-11E5-9242-09173F13E4C5 n15:271B43F7-363D-11E5-9242-09173F13E4C5 n15:271B43F8-363D-11E5-9242-09173F13E4C5 n15:271B43F9-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
Pancrelipase is not significantly absorbed from the gastrointestinal tract and acts locally, so there is no terminal elimination half life.
n3:indication
For treatment of exocrine pancreatic insufficiency in cystic fibrosis (Ultresa™), chronic pancreatitis (Viokace™ in combination with a proton pump inhibitor), and pancreatectomy (Viokace™ in combination with a proton pump inhibitor).
owl:sameAs
n9:DB00085 n21:DB00085
dcterms:title
Pancrelipase
adms:identifier
n5:P04746 n6:M18785 n7:54868-6067-0 n10:DB00085 n22:Pancrelipase n23:D05349 n24:PA448428
n3:mechanismOfAction
The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars.
n3:packager
n12:271B43DD-363D-11E5-9242-09173F13E4C5 n12:271B43DE-363D-11E5-9242-09173F13E4C5 n12:271B43DB-363D-11E5-9242-09173F13E4C5 n12:271B43DC-363D-11E5-9242-09173F13E4C5 n12:271B43E1-363D-11E5-9242-09173F13E4C5 n12:271B43E2-363D-11E5-9242-09173F13E4C5 n12:271B43DF-363D-11E5-9242-09173F13E4C5 n12:271B43E0-363D-11E5-9242-09173F13E4C5 n12:271B43E3-363D-11E5-9242-09173F13E4C5 n12:271B43D9-363D-11E5-9242-09173F13E4C5 n12:271B43DA-363D-11E5-9242-09173F13E4C5 n12:271B43D8-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
Pancrelipase is eliminated in the feces.
n3:synonym
PA 1,4-alpha-D- glucan glucanohydrolase Pancreatic alpha-amylase precursor
n3:toxicity
Overdose symptoms may include diarrhea or stomach upset. The most common adverse reactions seen are ear, neck, and abdominal pain; headache, nasal congestion, and beta-hemolytic streptococcal infection.
n3:volumeOfDistribution
Pancrelipase acts locally, so there is no volume of distribution.
n3:foodInteraction
Multivitamins/minerals which have vitamins ADEK, folate, or iron: If pancrelipase is used in combination with multivitamins/minerals that have vitamins ADEK, folate, or iron then monitor therapy because pancrelipase may decrease absorption of iron in these multivitamin/mineral products. Delayed release capsules should not be broken or crushed, but for those patients who cannot swallow the capsules, sprinkle the contents of the capsule onto soft acidic foods (pH of ≤4.5). Alkaline foods with a higher pH will promote early release of pancrelipase followed by enzyme inactivation in the stomach. Take pancrelipase with meals and a sufficient amount of water.
n3:proteinBinding
Pancrelipase acts locally, so there is minimal plasma protein binding.
n16:hasConcept
n17:M0045748
foaf:page
n14:pancrel.htm n18:amylase-lipase-protease.html
n3:Molecular-Formula
n19:271B4414-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n19:271B4413-363D-11E5-9242-09173F13E4C5
n3:absorption
Pancrelipase is not significantly absorbed from the gastrointestinal tract.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
53608-75-6
n3:category
n3:clearance
Pancrelipase is not significantly absorbed, so there is minimal clearance from the body.
n3:containedIn
n11:271B43F3-363D-11E5-9242-09173F13E4C5 n11:271B43F4-363D-11E5-9242-09173F13E4C5 n11:271B43F1-363D-11E5-9242-09173F13E4C5 n11:271B43F2-363D-11E5-9242-09173F13E4C5 n11:271B43E7-363D-11E5-9242-09173F13E4C5 n11:271B43E8-363D-11E5-9242-09173F13E4C5 n11:271B43EB-363D-11E5-9242-09173F13E4C5 n11:271B43EC-363D-11E5-9242-09173F13E4C5 n11:271B43E9-363D-11E5-9242-09173F13E4C5 n11:271B43EA-363D-11E5-9242-09173F13E4C5 n11:271B43EF-363D-11E5-9242-09173F13E4C5 n11:271B43F0-363D-11E5-9242-09173F13E4C5 n11:271B43ED-363D-11E5-9242-09173F13E4C5 n11:271B43EE-363D-11E5-9242-09173F13E4C5 n11:271B43E4-363D-11E5-9242-09173F13E4C5 n11:271B43E5-363D-11E5-9242-09173F13E4C5 n11:271B43E6-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n19:271B4412-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n19:271B4411-363D-11E5-9242-09173F13E4C5