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Namespace Prefixes

PrefixIRI
n12http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n20http://linked.opendata.cz/resource/AHFS/
foafhttp://xmlns.com/foaf/0.1/
n7http://linked.opendata.cz/resource/drugbank/company/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00081/identifier/genbank/
n6http://linked.opendata.cz/resource/drugbank/drug/DB00081/identifier/uniprotkb/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00081/identifier/wikipedia/
n21http://linked.opendata.cz/resource/drugbank/drug/DB00081/identifier/pharmgkb/
n18http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n16http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n14http://linked.opendata.cz/resource/drugbank/medicinal-product/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00081/identifier/drugbank/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n22http://www.drugs.com/cdi/
n4http://linked.opendata.cz/resource/drugbank/property/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00081/identifier/national-drug-code-directory/
xsdhhttp://www.w3.org/2001/XMLSchema#
n19http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00081
rdf:type
n3:Drug
n3:description
Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
n3:group
approved
n3:halfLife
0.8 hours (mammalian reticulocytes, in vitro)
n3:indication
For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)
owl:sameAs
n16:DB00081 n18:DB00081
dcterms:title
Tositumomab
adms:identifier
n6:P01857 n8:J00228 n9:0007-3260-31 n10:DB00081 n13:Tositumomab n21:PA164748364
n3:mechanismOfAction
Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation.
n3:packager
n7:271B43AA-363D-11E5-9242-09173F13E4C5 n7:271B43AB-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
Elimination of Iodine-131 occurs by decay and excretion in the urine.
n3:synonym
Ig gamma-1 chain C region
n19:hasAHFSCode
n20:10-00-00
foaf:page
n12:bexxar.htm n22:iodine-i-131-tositumomab.html
n3:Molecular-Formula
n4:271B43B2-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B43B1-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
192391-48-3
n3:clearance
* 68.2 mg/hr [patients with NHL]
n3:containedIn
n14:271B43AC-363D-11E5-9242-09173F13E4C5 n14:271B43AD-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n4:271B43AF-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B43B0-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B43AE-363D-11E5-9242-09173F13E4C5