This HTML5 document contains 33 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n10http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n12http://linked.opendata.cz/resource/drugbank/company/
n20http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/genbank/
foafhttp://xmlns.com/foaf/0.1/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/uniprotkb/
n13http://linked.opendata.cz/resource/drugbank/dosage/
n5http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/wikipedia/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/pharmgkb/
n16http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n7http://linked.opendata.cz/resource/drugbank/patent/
n15http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/drugbank/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n11http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n21http://www.drugs.com/cdi/
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB00078
rdf:type
n3:Drug
n3:description
Indium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each.
n3:dosage
n13:271B4397-363D-11E5-9242-09173F13E4C5
n3:generalReferences
#American Society of Health System Pharmacists, Inc., DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995. Ibritumomab; [updated 2013 Jan 18; cited 2014 Nov 24]. Available from http://web.b.ebscohost.com/dynamed/detail?vid=6&sid=48a6db20-234e-4280-b18e-dcd0e2fed388%40sessionmgr198&hid=102&bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d#db=dme&AN=232878 #Lexicomp Online (2014). Ibritumomab. Available at:http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7065#f_pharmacology-and-pharmacokinetics [Accessed 24 Nov. 2014].
n3:group
approved
n3:halfLife
0.8 hours (mammalian reticulocytes, in vitro)
n3:indication
For treatment of non-Hodgkin's lymphoma
owl:sameAs
n15:DB00078 n16:DB00078
dcterms:title
Ibritumomab
adms:identifier
n5:Ibritumomab n8:PA164781375 n18:P01865 n19:DB00078 n20:J00470
n3:mechanismOfAction
The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles.
n3:packager
n12:271B4394-363D-11E5-9242-09173F13E4C5
n3:patent
n7:2149329
n3:synonym
Ig gamma-2A chain C region, membrane-bound form radiolabeled murine anti-CD20
n3:volumeOfDistribution
Binding observed on lymphoid cells of the bone marrow, lymph node, thymus, red and white pulp of the spleen, lymphoid follicles of the tonsil, and lymphoid nodules of other organs (e.g., large and small intestines)
foaf:page
n10:zevalin.htm n21:ibritumomab-tiuxetan-with-indium-111.html
n3:Molecular-Formula
n6:271B439C-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n6:271B439B-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
174722-31-7
n3:clearance
Approximately 7.2% of injected dose of yttrium Y 90 ibritumomab tiuxetan is excreted in urine within 7 days.
n3:containedIn
n11:271B4395-363D-11E5-9242-09173F13E4C5 n11:271B4396-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n6:271B4399-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n6:271B439A-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n6:271B4398-363D-11E5-9242-09173F13E4C5