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Namespace Prefixes

PrefixIRI
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n14http://linked.opendata.cz/resource/drugbank/company/
n9http://linked.opendata.cz/resource/drugbank/dosage/
n4http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/drugbank/
n25http://bio2rdf.org/drugbank:
n10http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/national-drug-code-directory/
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n13http://linked.opendata.cz/resource/drugbank/property/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/genbank/
xsdhhttp://www.w3.org/2001/XMLSchema#
n12http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/uniprotkb/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/wikipedia/
n7http://linked.opendata.cz/resource/atc/
n6http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00074
rdf:type
n5:Drug
n5:description
A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha.
n5:dosage
n9:271B437B-363D-11E5-9242-09173F13E4C5 n9:271B437C-363D-11E5-9242-09173F13E4C5 n9:271B437A-363D-11E5-9242-09173F13E4C5
n5:group
investigational approved
n5:halfLife
7.2 +/- 3.2 days (adults)
n5:indication
For prophylactic treatment of kidney transplant rejection
owl:sameAs
n19:DB00074 n25:DB00074
dcterms:title
Basiliximab
adms:identifier
n4:DB00074 n10:0078-0393-61 n11:J00228 n12:P01857 n15:Basiliximab n16:PA164747126
n5:mechanismOfAction
Basiliximab binds with high-affinity to the alpha-subunit (CD25) of the high-affinity IL-2 receptor. This inhibits IL-2 binding, which inhibits T-cell activation and prevents the body from mounting an immune response against the foreign kidney.
n5:packager
n14:271B4377-363D-11E5-9242-09173F13E4C5
n5:patent
n24:2038279
n5:synonym
chimeric mouse-human antiCD25 Ig gamma-1 chain C region
n5:volumeOfDistribution
* 7.8 ± 5.1 L [Pediatric] * 4.8 ± 2.1 L [Adult]
n6:hasAHFSCode
n27:92-00-00
n22:hasConcept
n23:M0292349
foaf:page
n21:basiliximab.html n26:basiliximab.htm
n5:Molecular-Formula
n13:271B4381-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n13:271B4380-363D-11E5-9242-09173F13E4C5
n6:hasATCCode
n7:L04AC02
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
152923-56-3
n5:category
n5:clearance
* 41 +/- 19 mL/h [Adult patients undergoing first kidney transplantation] * 17 +/- 6 mL/h [pediatric patients undergoing renal transplantation] * 31 +/- 19 mL/h [adolescent patients undergoing renal transplantation]
n5:containedIn
n8:271B4378-363D-11E5-9242-09173F13E4C5 n8:271B4379-363D-11E5-9242-09173F13E4C5
n5:Hydrophobicity
n13:271B437E-363D-11E5-9242-09173F13E4C5
n5:Isoelectric-Point
n13:271B437F-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n13:271B437D-363D-11E5-9242-09173F13E4C5