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Namespace Prefixes

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Statements

Subject Item
n2:DB00070
rdf:type
n5:Drug
n5:description
Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.
n5:dosage
n22:271B4350-363D-11E5-9242-09173F13E4C5 n22:271B4351-363D-11E5-9242-09173F13E4C5 n22:271B4352-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Csoka AB, Scherer SW, Stern R: Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. Genomics. 1999 Sep 15;60(3):356-61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10493834
n5:group
investigational approved
n5:indication
For increase of absorption and distribution of other injected drugs and for rehydration.
n5:manufacturer
n12:271B4348-363D-11E5-9242-09173F13E4C5 n12:271B434B-363D-11E5-9242-09173F13E4C5 n12:271B4349-363D-11E5-9242-09173F13E4C5 n12:271B434A-363D-11E5-9242-09173F13E4C5
owl:sameAs
n19:DB00070 n24:DB00070
dcterms:title
Hyaluronidase
adms:identifier
n4:Hyaluronidase n8:L13781 n9:DB00070 n10:P38567 n11:0548-9090-10 n25:PA164745713
n5:mechanismOfAction
Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
n5:packager
n12:271B4347-363D-11E5-9242-09173F13E4C5 n12:271B4345-363D-11E5-9242-09173F13E4C5 n12:271B4346-363D-11E5-9242-09173F13E4C5 n12:271B4343-363D-11E5-9242-09173F13E4C5 n12:271B4344-363D-11E5-9242-09173F13E4C5 n12:271B4341-363D-11E5-9242-09173F13E4C5 n12:271B4342-363D-11E5-9242-09173F13E4C5 n12:271B433F-363D-11E5-9242-09173F13E4C5 n12:271B4340-363D-11E5-9242-09173F13E4C5 n12:271B433E-363D-11E5-9242-09173F13E4C5
n5:synonym
Sperm surface protein PH-20 Hyaluronidase 1 precursor Hyaluronidase PH-20 HYAL-1 Sperm adhesion molecule 1
n5:synthesisReference
Yasuhiro Mima, Masaaki Yamada, "Preparation of human placental hyaluronidase." U.S. Patent US3945889, issued October, 1957.
n20:hasConcept
n21:M0010666
foaf:page
n16:hylenex.htm n17:hyaluronidase.html
n5:Molecular-Formula
n6:271B4356-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B4355-363D-11E5-9242-09173F13E4C5
n13:hasATCCode
n14:B06AA03
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
488712-31-8
n5:category
n5:containedIn
n7:271B434D-363D-11E5-9242-09173F13E4C5 n7:271B434E-363D-11E5-9242-09173F13E4C5 n7:271B434C-363D-11E5-9242-09173F13E4C5 n7:271B434F-363D-11E5-9242-09173F13E4C5
n5:Hydrophobicity
n6:271B4353-363D-11E5-9242-09173F13E4C5
n5:Isoelectric-Point
n6:271B4354-363D-11E5-9242-09173F13E4C5