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Namespace Prefixes

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Statements

Subject Item
n2:DB00067
rdf:type
n3:Drug
n3:description
Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation
n3:dosage
n4:271B4320-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ: Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology. 2004 Mar;29(3):483-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14647484 # Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu SB, Young WS 3rd: Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav. 2007 Aug;6(6):540-51. Epub 2006 Nov 3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17083331 # Lolait SJ, Stewart LQ, Jessop DS, Young WS 3rd, O'Carroll AM: The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology. 2007 Feb;148(2):849-56. Epub 2006 Nov 22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17122081 # Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS 3rd: Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Horm Behav. 2004 Dec;46(5):638-45. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15555506 # Kanwar S, Woodman RC, Poon MC, Murohara T, Lefer AM, Davenpeck KL, Kubes P: Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules. Blood. 1995 Oct 1;86(7):2760-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7545469
n3:group
approved
n3:halfLife
10-20 minutes
n3:indication
For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
n3:manufacturer
n12:271B431C-363D-11E5-9242-09173F13E4C5
owl:sameAs
n11:DB00067 n25:DB00067
dcterms:title
Vasopressin
adms:identifier
n14:Vasopressin n20:PA451858 n21:C00840 n22:D00101 n23:DB00067
n3:mechanismOfAction
Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
n3:packager
n12:271B4313-363D-11E5-9242-09173F13E4C5 n12:271B4314-363D-11E5-9242-09173F13E4C5 n12:271B4317-363D-11E5-9242-09173F13E4C5 n12:271B4318-363D-11E5-9242-09173F13E4C5 n12:271B4315-363D-11E5-9242-09173F13E4C5 n12:271B4316-363D-11E5-9242-09173F13E4C5 n12:271B431B-363D-11E5-9242-09173F13E4C5 n12:271B4319-363D-11E5-9242-09173F13E4C5 n12:271B431A-363D-11E5-9242-09173F13E4C5
n3:synonym
Antidiuretic hormone Arginine vasopressin Argipressin AVP ADH
n17:hasAHFSCode
n24:68-28-00
n3:foodInteraction
Ethanol
n3:proteinBinding
1%
n3:synthesisReference
Nedumparambil A. Abraham, Hans U. Immer, Kazimir Sestanj, "Process for producing triglycyl-lysine vasopressin and intermediates therefor." U.S. Patent US4093610, issued June, 1963.
n8:hasConcept
n9:M0494241
foaf:page
n7:vasopressin.html n19:vasopressin.htm
n3:Molecular-Formula
n16:271B4324-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n16:271B4323-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n16:271B4321-363D-11E5-9242-09173F13E4C5
n17:hasATCCode
n18:H01BA01
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
11000-17-2
n3:category
n3:containedIn
n15:271B431D-363D-11E5-9242-09173F13E4C5 n15:271B431E-363D-11E5-9242-09173F13E4C5 n15:271B431F-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n16:271B4322-363D-11E5-9242-09173F13E4C5