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Statements

Subject Item
n2:DB00066
rdf:type
n3:Drug
n3:description
Follitropin beta is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH.
n3:dosage
n16:271B430B-363D-11E5-9242-09173F13E4C5 n16:271B430C-363D-11E5-9242-09173F13E4C5 n16:271B430D-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Goa KL, Wagstaff AJ: Follitropin alpha in infertility: a review. BioDrugs. 1998 Mar;9(3):235-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18020563
n3:group
approved
n3:halfLife
Circulation half life of 3-4 hours, elimination half life of 35-40 hours
n3:indication
For treatment of female infertility
n3:manufacturer
n12:271B42FE-363D-11E5-9242-09173F13E4C5 n12:271B42FF-363D-11E5-9242-09173F13E4C5
owl:sameAs
n14:DB00066 n25:DB00066
dcterms:title
Follitropin beta
adms:identifier
n6:DB00066 n8:P01225 n9:0052-0306-31 n10:PA449693 n11:Follicle-stimulating_hormone n26:M16647
n3:mechanismOfAction
Follitropin alpha is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
n3:packager
n12:271B42FC-363D-11E5-9242-09173F13E4C5 n12:271B42FD-363D-11E5-9242-09173F13E4C5 n12:271B42FB-363D-11E5-9242-09173F13E4C5
n3:patent
n17:5270057 n17:2037884 n17:7741268
n3:routeOfElimination
Via liver and kidneys
n3:synonym
Follicle-stimulating hormone beta subunit Follicle stimulating hormone beta FSH-beta FSH-B FSH-b Follitropin beta Follitropin beta chain precursor Follitrophin beta
n3:volumeOfDistribution
* 8 L [female subjects following intravenous administration of a 300 IU dose]
n20:hasConcept
n21:M0573063
foaf:page
n19:follitropin-alfa-powder.html n22:follitrop.htm
n3:Molecular-Formula
n4:271B4312-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4311-363D-11E5-9242-09173F13E4C5
n23:hasATCCode
n24:G03GA06
n3:absorption
74%
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9002-68-0
n3:category
n3:clearance
* 0.01 1*h-1kg-1 [European women with a single intramuscular dose of 300 IU] * 0.01 1*h-1kg-1 [Japanese women with a single intramuscular dose of 300 IU]
n3:containedIn
n7:271B4300-363D-11E5-9242-09173F13E4C5 n7:271B4309-363D-11E5-9242-09173F13E4C5 n7:271B430A-363D-11E5-9242-09173F13E4C5 n7:271B4307-363D-11E5-9242-09173F13E4C5 n7:271B4308-363D-11E5-9242-09173F13E4C5 n7:271B4305-363D-11E5-9242-09173F13E4C5 n7:271B4306-363D-11E5-9242-09173F13E4C5 n7:271B4303-363D-11E5-9242-09173F13E4C5 n7:271B4304-363D-11E5-9242-09173F13E4C5 n7:271B4301-363D-11E5-9242-09173F13E4C5 n7:271B4302-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n4:271B430F-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B4310-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B430E-363D-11E5-9242-09173F13E4C5