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Namespace Prefixes

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Statements

Subject Item
n2:DB00061
rdf:type
n5:Drug
n5:description
Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.
n5:dosage
n19:271B42B5-363D-11E5-9242-09173F13E4C5
n5:generalReferences
#Lexicomp Online (2014). Pegademase Bovine. Available at:http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7443#f_pharmacology-and-pharmacokinetics [Accessed 12 Nov. 2014].
n5:group
approved
n5:halfLife
plasma adenosine deaminase elimination half-life is 3 to >6 days
n5:indication
For treatment of adenosine deaminase deficiency
n5:manufacturer
n7:271B42B3-363D-11E5-9242-09173F13E4C5
owl:sameAs
n15:DB00061 n18:DB00061
dcterms:title
Pegademase bovine
adms:identifier
n4:P56658 n6:57665-001-01 n8:PA450831 n16:DB00061 n17:AF280603
n5:mechanismOfAction
Pegademase converts adenosine (toxic) to inosine (less toxic) by deamination. It also converts 2'-deoxyadenosine to 2'-deoxyinosine via deamination.
n5:packager
n7:271B42B2-363D-11E5-9242-09173F13E4C5 n7:271B42B1-363D-11E5-9242-09173F13E4C5
n5:synonym
Adenosine deaminase Adenosine aminohydrolase
n5:synthesisReference
Paul Skonezny, "Process for preparing dideoxyinosine using adenosine deaminase enzyme." U.S. Patent US20040175804, issued September 09, 2004.
n9:hasConcept
n10:M0146358
foaf:page
n12:pegademase.htm n20:pegademase-bovine.html
n5:Molecular-Formula
n13:271B42B9-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n13:271B42B8-363D-11E5-9242-09173F13E4C5
n5:absorption
Time to peak for plasma adenosine deaminase is 2 to 3 days
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
9026-93-1
n5:category
n5:containedIn
n22:271B42B4-363D-11E5-9242-09173F13E4C5
n5:Hydrophobicity
n13:271B42B6-363D-11E5-9242-09173F13E4C5
n5:Isoelectric-Point
n13:271B42B7-363D-11E5-9242-09173F13E4C5