. "investigational"@en . . . . . . "145258-61-3"@en . . . "Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha."@en . . "For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum"@en . . . . . . . "Interferon beta precursor"@en . "approved"@en . . . . "Heinz-Jurgen Friesen, Sidney Pestka, \"Preparation of homogeneous human fibroblast interferon.\" U.S. Patent US4289689, issued December, 1968."@en . "Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence of Avonex is identical to that of natural human interferon beta."@en . . . . "IFN-beta"@en . . . . . . "Fibroblast interferon"@en . . . . . . . . . . . . " "@en . . "10 hrs"@en . . . "* 33-55 L/hour [Healthy SC injection of 60 mcg]"@en . "Interferon beta-1a"@en . . . .