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Namespace Prefixes

PrefixIRI
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n27http://linked.opendata.cz/resource/atc/
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Statements

Subject Item
n2:DB00060
rdf:type
n3:Drug
n3:description
Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence of Avonex is identical to that of natural human interferon beta.
n3:dosage
n15:271B42AB-363D-11E5-9242-09173F13E4C5 n15:271B42AC-363D-11E5-9242-09173F13E4C5 n15:271B42A7-363D-11E5-9242-09173F13E4C5 n15:271B42A8-363D-11E5-9242-09173F13E4C5 n15:271B42A9-363D-11E5-9242-09173F13E4C5 n15:271B42AA-363D-11E5-9242-09173F13E4C5 n15:271B42A3-363D-11E5-9242-09173F13E4C5 n15:271B42A4-363D-11E5-9242-09173F13E4C5 n15:271B42A5-363D-11E5-9242-09173F13E4C5 n15:271B42A6-363D-11E5-9242-09173F13E4C5 n15:271B42A1-363D-11E5-9242-09173F13E4C5 n15:271B42A2-363D-11E5-9242-09173F13E4C5
n3:group
investigational approved
n3:halfLife
10 hrs
n3:indication
For treatment of relapsing/remitting multiple sclerosis, also for condyloma acuminatum
n3:manufacturer
n18:271B429B-363D-11E5-9242-09173F13E4C5
owl:sameAs
n10:DB00060 n21:DB00060
dcterms:title
Interferon beta-1a
adms:identifier
n6:PA450037 n7:DB00060 n8:Interferon_beta-1a n23:44087-8822-1 n24:V00534 n26:P01574
n3:mechanismOfAction
Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.
n3:packager
n18:271B4296-363D-11E5-9242-09173F13E4C5 n18:271B4297-363D-11E5-9242-09173F13E4C5 n18:271B4295-363D-11E5-9242-09173F13E4C5 n18:271B429A-363D-11E5-9242-09173F13E4C5 n18:271B4298-363D-11E5-9242-09173F13E4C5 n18:271B4299-363D-11E5-9242-09173F13E4C5
n3:patent
n11:1341604
n3:synonym
Interferon beta precursor IFN-beta Fibroblast interferon
n16:hasAHFSCode
n17:92-00-00
n3:synthesisReference
Heinz-Jurgen Friesen, Sidney Pestka, "Preparation of homogeneous human fibroblast interferon." U.S. Patent US4289689, issued December, 1968.
n19:hasConcept
n20:M0230367
foaf:page
n14:rebif.htm n22:interferon-beta-1a.html
n3:Molecular-Formula
n4:271B42B0-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B42AF-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n27:L03AB07
n3:casRegistryNumber
145258-61-3
n3:category
n3:clearance
* 33-55 L/hour [Healthy SC injection of 60 mcg]
n3:containedIn
n12:271B429F-363D-11E5-9242-09173F13E4C5 n12:271B42A0-363D-11E5-9242-09173F13E4C5 n12:271B429D-363D-11E5-9242-09173F13E4C5 n12:271B429E-363D-11E5-9242-09173F13E4C5 n12:271B429C-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n4:271B42AD-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B42AE-363D-11E5-9242-09173F13E4C5