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Namespace Prefixes

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Statements

Subject Item
n2:DB00059
rdf:type
n3:Drug
n3:description
Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life.
n3:dosage
n8:271B4290-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Graham ML: Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev. 2003 Sep 26;55(10):1293-302. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14499708 #Lexicomp Online (2014). Pegaspargase. Available at:http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7445#f_adverse-reactions [Accessed 12 Nov. 2014]. #American Society of Health System Pharmacists, Inc., DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995. Pegaspargase; [updated 2013 Jan 18; cited 2014 Nov 12]. Available from http://search.ebscohost.com/login.aspx?direct=true&site=DynaMed&id=233015.
n3:group
approved investigational
n3:halfLife
IM: ~6 days; half-life decreased to ~3 days (range: 1.4 to 5 days) in patients with previous hypersensitivity to native L-asparaginase; IV: Adults (asparaginase naive): 7 days
n3:indication
For treatment of acute lymphoblastic leukemia
owl:sameAs
n14:DB00059 n19:DB00059
dcterms:title
Pegaspargase
adms:identifier
n17:PA164760860 n18:Pegaspargase n20:P37595 n22:U00096 n23:57665-002-02 n25:DB00059
n3:mechanismOfAction
Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.
n3:packager
n9:271B428E-363D-11E5-9242-09173F13E4C5 n9:271B428D-363D-11E5-9242-09173F13E4C5
n3:synonym
L-asparagine amidohydrolase Putative L-asparaginase precursor
n3:toxicity
Adverse effects that occur more than 10% of the time include hepatotoxicity as it is known to increase serum transaminases (ALT, AST). Also known to induce hypersensitivity reactions including anaphylaxis, erythema and bronchospasm.
n3:volumeOfDistribution
IV: Adults (asparaginase naive): 2.4 L/m2 Distributes into CSF (reportedly reducing CSF asparagine concentrations to a similar extent as asparaginase
n4:hasConcept
n5:M0125979
foaf:page
n7:pegaspargase.htm n10:pegaspargase.html
n3:Molecular-Formula
n21:271B4294-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n21:271B4293-363D-11E5-9242-09173F13E4C5
n11:hasATCCode
n12:L01XX24
n3:absorption
Onset of Asparagine depletion by IM is within 4 days Time to peak: IM: 3 to 4 days
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
130167-69-0
n3:category
n3:containedIn
n24:271B428F-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n21:271B4291-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n21:271B4292-363D-11E5-9242-09173F13E4C5