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Namespace Prefixes

PrefixIRI
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n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
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Statements

Subject Item
n2:DB00058
rdf:type
n3:Drug
n3:description
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
n3:dosage
n5:271B4287-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Karnaukhova E, Ophir Y, Golding B: Recombinant human alpha-1 proteinase inhibitor: towards therapeutic use. Amino Acids. 2006 Jun;30(4):317-32. Epub 2006 May 26. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16773239
n3:group
approved
n3:indication
For treatment of panacinar emphysema
owl:sameAs
n8:DB00058 n20:DB00058
dcterms:title
Alpha-1-proteinase inhibitor
adms:identifier
n12:K01396 n13:DB00058 n14:P01009 n15:0944-2802-01 n16:PA10308 n17:Alpha_1-antitrypsin
n3:mechanismOfAction
Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
n3:packager
n6:271B427D-363D-11E5-9242-09173F13E4C5 n6:271B427E-363D-11E5-9242-09173F13E4C5 n6:271B427C-363D-11E5-9242-09173F13E4C5
n3:synonym
Alpha-1 protease inhibitor Alpha-1-antiproteinase Alpha-1-antitrypsin precursor Alpha 1-antitrypsin
n3:volumeOfDistribution
* 5632 ± 2006 mL [ARALAST NP] * 5618 ± 1618 mL [Aralast]
n3:synthesisReference
Michael H. Coan, William J. Brockway, "Method of preparing alpha-1-proteinase inhibitor." U.S. Patent US4379087, issued December, 1968.
foaf:page
n19:zemaira.htm
n3:Molecular-Formula
n4:271B428C-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B428B-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9041-92-3
n3:category
n3:clearance
* 940 +/- 275 mL/day [Patients with congenital α1-PI deficiency with single IV infusion of 60 mg/kg]
n3:containedIn
n10:271B4283-363D-11E5-9242-09173F13E4C5 n10:271B4284-363D-11E5-9242-09173F13E4C5 n10:271B4281-363D-11E5-9242-09173F13E4C5 n10:271B4282-363D-11E5-9242-09173F13E4C5 n10:271B427F-363D-11E5-9242-09173F13E4C5 n10:271B4280-363D-11E5-9242-09173F13E4C5 n10:271B4285-363D-11E5-9242-09173F13E4C5 n10:271B4286-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n4:271B4289-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B428A-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B4288-363D-11E5-9242-09173F13E4C5