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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n5http://linked.opendata.cz/resource/drugbank/company/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00057/identifier/pharmgkb/
n11http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n8http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00057/identifier/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB00057
rdf:type
n3:Drug
n3:description
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
n3:generalReferences
# Artiko V, Obradovic V, Davidovic B, Petrovic N, Petrovic M, Krivokapic Z, Kecmanovic D, Pesko P, Djukic V, Milosavljevic T, Adanja G, Vlajkovic M: Radioimmunodetection of colorectal carcinoma. Hepatogastroenterology. 2003 Jul-Aug;50(52):1029-31. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12845972 # Bohdiewicz PJ: Indium-111 satumomab pendetide: the first FDA-approved monoclonal antibody for tumor imaging. J Nucl Med Technol. 1998 Sep;26(3):155-63; quiz 170-1. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/ 9755434
n3:group
withdrawn approved
n3:halfLife
0.8 hours (mammalian reticulocytes, in vitro)
n3:indication
For diagnosis of extrahepatic malignant cancers
owl:sameAs
n8:DB00057 n11:DB00057
dcterms:title
Satumomab Pendetide
adms:identifier
n10:DB00057 n12:PA164745371
n3:mechanismOfAction
Satumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
n3:packager
n5:271B4276-363D-11E5-9242-09173F13E4C5
n3:synonym
Indium-111 satumomab pendetide Indium (111In) satumomab pendetide
n3:Molecular-Formula
n4:271B427B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B427A-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
138955-26-7
n3:category
n3:Hydrophobicity
n4:271B4278-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B4279-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B4277-363D-11E5-9242-09173F13E4C5