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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB00052
rdf:type
n3:Drug
n3:description
Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli
n3:dosage
n9:271B424D-363D-11E5-9242-09173F13E4C5 n9:271B4249-363D-11E5-9242-09173F13E4C5 n9:271B424A-363D-11E5-9242-09173F13E4C5 n9:271B424B-363D-11E5-9242-09173F13E4C5 n9:271B424C-363D-11E5-9242-09173F13E4C5 n9:271B4245-363D-11E5-9242-09173F13E4C5 n9:271B4246-363D-11E5-9242-09173F13E4C5 n9:271B4247-363D-11E5-9242-09173F13E4C5 n9:271B4248-363D-11E5-9242-09173F13E4C5 n9:271B4242-363D-11E5-9242-09173F13E4C5 n9:271B4243-363D-11E5-9242-09173F13E4C5 n9:271B4244-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Seltzer V, Tonge SR: Proceedings: Methylamphetamine withdrawal as a model for the depressive state: antagonism of post-amphetamine depression by imipramine. J Pharm Pharmacol. 1975 Dec;27 Suppl?-2:16P. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2688 # Alba-Roth J, Muller OA, Schopohl J, von Werder K: Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2903866 # Scarth JP: Modulation of the growth hormone-insulin-like growth factor (GH-IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review. Xenobiotica. 2006 Feb-Mar;36(2-3):119-218. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16702112 # Takahashi Y, Kipnis DM, Daughaday WH: Growth hormone secretion during sleep. J Clin Invest. 1968 Sep;47(9):2079-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5675428
n3:group
approved investigational
n3:indication
For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss
n3:manufacturer
n10:271B420B-363D-11E5-9242-09173F13E4C5 n10:271B420C-363D-11E5-9242-09173F13E4C5 n10:271B4209-363D-11E5-9242-09173F13E4C5 n10:271B420A-363D-11E5-9242-09173F13E4C5 n10:271B420D-363D-11E5-9242-09173F13E4C5 n10:271B420E-363D-11E5-9242-09173F13E4C5 n10:271B4207-363D-11E5-9242-09173F13E4C5 n10:271B4208-363D-11E5-9242-09173F13E4C5 n10:271B4205-363D-11E5-9242-09173F13E4C5 n10:271B4206-363D-11E5-9242-09173F13E4C5
owl:sameAs
n17:DB00052 n20:DB00052
dcterms:title
Somatropin recombinant
adms:identifier
n6:DB00052 n11:PA451446 n12:Somatropin_recombinant n22:0169-7704-21 n23:AF374232 n24:P58756
n3:mechanismOfAction
hGH binds to the human growth hormone receptor (GHR). Upon binding, hGH causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activate a variety of signaling molecules, including MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol, protein kinase C, intracellular calcium, and Stat transcription factors. These signaling molecules contribute to the GH-induced changes in enzymatic activity, transport function, and gene expression that ultimately culminate in changes in growth and metabolism.
n3:packager
n10:271B41EF-363D-11E5-9242-09173F13E4C5 n10:271B41F0-363D-11E5-9242-09173F13E4C5 n10:271B4203-363D-11E5-9242-09173F13E4C5 n10:271B4204-363D-11E5-9242-09173F13E4C5 n10:271B4201-363D-11E5-9242-09173F13E4C5 n10:271B4202-363D-11E5-9242-09173F13E4C5 n10:271B41F7-363D-11E5-9242-09173F13E4C5 n10:271B41F8-363D-11E5-9242-09173F13E4C5 n10:271B41F5-363D-11E5-9242-09173F13E4C5 n10:271B41F6-363D-11E5-9242-09173F13E4C5 n10:271B41F3-363D-11E5-9242-09173F13E4C5 n10:271B41F4-363D-11E5-9242-09173F13E4C5 n10:271B41F1-363D-11E5-9242-09173F13E4C5 n10:271B41F2-363D-11E5-9242-09173F13E4C5 n10:271B41FF-363D-11E5-9242-09173F13E4C5 n10:271B4200-363D-11E5-9242-09173F13E4C5 n10:271B41FD-363D-11E5-9242-09173F13E4C5 n10:271B41FE-363D-11E5-9242-09173F13E4C5 n10:271B41FB-363D-11E5-9242-09173F13E4C5 n10:271B41FC-363D-11E5-9242-09173F13E4C5 n10:271B41F9-363D-11E5-9242-09173F13E4C5 n10:271B41FA-363D-11E5-9242-09173F13E4C5
n3:patent
n7:2252535 n7:6152897 n7:1326439 n7:5288703
n3:routeOfElimination
Although calcium excretion in the urine is increased, there is a simultaneous increase in calcium absorption from the intestine. Somatropin stimulates the synthesis of chondroitin sulfate and collagen, and increases the urinary excretion of hydroxyproline.
n3:synonym
GH Growth hormone 1 Pituitary growth hormone GH-N Somatotropin precursor Somatropin Growth hormone
n3:synthesisReference
Mandayam J. Narasimhan, John A. Anderson, "Process for the large scale production of human growth hormone by serial secondary suspension culture." U.S. Patent US4124448, issued January, 1963.
foaf:page
n19:nutropin.htm n21:somatropin-rdna-origin-nonrefrigerated.html
n3:Molecular-Formula
n15:271B4252-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n15:271B4251-363D-11E5-9242-09173F13E4C5
n13:hasATCCode
n14:H01AC01
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
12629-01-5
n3:category
n3:clearance
* 2.3 +/- 1.8 mL/min/kg [GHD patients (IV 33 ng/kg/min)]
n3:containedIn
n4:271B4217-363D-11E5-9242-09173F13E4C5 n4:271B4218-363D-11E5-9242-09173F13E4C5 n4:271B4215-363D-11E5-9242-09173F13E4C5 n4:271B4216-363D-11E5-9242-09173F13E4C5 n4:271B4213-363D-11E5-9242-09173F13E4C5 n4:271B4214-363D-11E5-9242-09173F13E4C5 n4:271B421B-363D-11E5-9242-09173F13E4C5 n4:271B4219-363D-11E5-9242-09173F13E4C5 n4:271B421A-363D-11E5-9242-09173F13E4C5 n4:271B4240-363D-11E5-9242-09173F13E4C5 n4:271B4241-363D-11E5-9242-09173F13E4C5 n4:271B423E-363D-11E5-9242-09173F13E4C5 n4:271B423F-363D-11E5-9242-09173F13E4C5 n4:271B4234-363D-11E5-9242-09173F13E4C5 n4:271B4235-363D-11E5-9242-09173F13E4C5 n4:271B4232-363D-11E5-9242-09173F13E4C5 n4:271B4233-363D-11E5-9242-09173F13E4C5 n4:271B4230-363D-11E5-9242-09173F13E4C5 n4:271B4231-363D-11E5-9242-09173F13E4C5 n4:271B422E-363D-11E5-9242-09173F13E4C5 n4:271B422F-363D-11E5-9242-09173F13E4C5 n4:271B423C-363D-11E5-9242-09173F13E4C5 n4:271B423D-363D-11E5-9242-09173F13E4C5 n4:271B423A-363D-11E5-9242-09173F13E4C5 n4:271B423B-363D-11E5-9242-09173F13E4C5 n4:271B4238-363D-11E5-9242-09173F13E4C5 n4:271B4239-363D-11E5-9242-09173F13E4C5 n4:271B4236-363D-11E5-9242-09173F13E4C5 n4:271B4237-363D-11E5-9242-09173F13E4C5 n4:271B4224-363D-11E5-9242-09173F13E4C5 n4:271B4225-363D-11E5-9242-09173F13E4C5 n4:271B4222-363D-11E5-9242-09173F13E4C5 n4:271B4223-363D-11E5-9242-09173F13E4C5 n4:271B4220-363D-11E5-9242-09173F13E4C5 n4:271B4221-363D-11E5-9242-09173F13E4C5 n4:271B421E-363D-11E5-9242-09173F13E4C5 n4:271B421F-363D-11E5-9242-09173F13E4C5 n4:271B422C-363D-11E5-9242-09173F13E4C5 n4:271B422D-363D-11E5-9242-09173F13E4C5 n4:271B422A-363D-11E5-9242-09173F13E4C5 n4:271B422B-363D-11E5-9242-09173F13E4C5 n4:271B4228-363D-11E5-9242-09173F13E4C5 n4:271B4229-363D-11E5-9242-09173F13E4C5 n4:271B4226-363D-11E5-9242-09173F13E4C5 n4:271B4227-363D-11E5-9242-09173F13E4C5 n4:271B4211-363D-11E5-9242-09173F13E4C5 n4:271B4212-363D-11E5-9242-09173F13E4C5 n4:271B420F-363D-11E5-9242-09173F13E4C5 n4:271B4210-363D-11E5-9242-09173F13E4C5 n4:271B421C-363D-11E5-9242-09173F13E4C5 n4:271B421D-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n15:271B424F-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n15:271B4250-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n15:271B424E-363D-11E5-9242-09173F13E4C5