. . . . " "@en . . "Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus."@en . . . . "Urate oxidase"@en . . . . "134774-45-1"@en . "approved"@en . . . . "Humans and other mammals"@en . . "Roy Eugene Snoke, Hugh Arthur Risley, Charles Thomas Goodhue, \"Production of uricase from micrococcus luteus.\" U.S. Patent US4062731, issued May, 1974."@en . "For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)"@en . . . "investigational"@en . . "* 110 to 127 mL/kg [pediatric patients] * 75.8 to 138 mL/kg [adult patients]"@en . . "Rasburicase"@en . . "# Giraldez M: A single, fixed dose of Rasburicase (6 mg maximum) for Treatment of Tumor Lysis Syndrome in Adults. Eur J Haematol. 2010 Apr 12. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/ 20394650 # Collings I, Watier Y, Giffard M, Dagogo S, Kahn R, Bonnete F, Wright JP, Fitch AN, Margiolaki I: Polymorphism of microcrystalline urate oxidase from Aspergillus flavus. Acta Crystallogr D Biol Crystallogr. 2010 May;66(Pt 5):539-48. Epub 2010 Apr 21. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/20445229"@en . . . "Uricase"@en . . . . "18 hours"@en . . "Rasburicase catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin)."@en .