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Namespace Prefixes

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Statements

Subject Item
n2:DB00049
rdf:type
n5:Drug
n5:description
Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified <i>Saccharomyces cerevisiae</i> strain. The cDNA coding for rasburicase was cloned from a strain of <i>Aspergillus flavus</i>.
n5:dosage
n6:271B41B7-363D-11E5-9242-09173F13E4C5 n6:271B41B8-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Giraldez M: A single, fixed dose of Rasburicase (6 mg maximum) for Treatment of Tumor Lysis Syndrome in Adults. Eur J Haematol. 2010 Apr 12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/ 20394650 # Collings I, Watier Y, Giffard M, Dagogo S, Kahn R, Bonnete F, Wright JP, Fitch AN, Margiolaki I: Polymorphism of microcrystalline urate oxidase from Aspergillus flavus. Acta Crystallogr D Biol Crystallogr. 2010 May;66(Pt 5):539-48. Epub 2010 Apr 21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20445229
n5:group
approved investigational
n5:halfLife
18 hours
n5:indication
For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)
owl:sameAs
n11:DB00049 n14:DB00049
dcterms:title
Rasburicase
adms:identifier
n8:PA10176 n9:Q00511 n12:X61766 n13:0024-5150-10 n15:DB00049 n25:Rasburicase
n5:mechanismOfAction
Rasburicase catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin).
n5:packager
n16:271B41B4-363D-11E5-9242-09173F13E4C5 n16:271B41B3-363D-11E5-9242-09173F13E4C5
n5:patent
n22:2148537 n22:2175971
n5:synonym
Urate oxidase Uricase
n5:volumeOfDistribution
* 110 to 127 mL/kg [pediatric patients] * 75.8 to 138 mL/kg [adult patients]
n17:hasAHFSCode
n20:44-00-00
n5:synthesisReference
Roy Eugene Snoke, Hugh Arthur Risley, Charles Thomas Goodhue, "Production of uricase from micrococcus luteus." U.S. Patent US4062731, issued May, 1974.
n26:hasConcept
n27:M0443962
foaf:page
n4:elitek.htm n19:rasburicase.html
n5:Molecular-Formula
n21:271B41BC-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n21:271B41BB-363D-11E5-9242-09173F13E4C5
n17:hasATCCode
n18:V03AF07
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
134774-45-1
n5:category
n5:containedIn
n24:271B41B5-363D-11E5-9242-09173F13E4C5 n24:271B41B6-363D-11E5-9242-09173F13E4C5
n5:Hydrophobicity
n21:271B41B9-363D-11E5-9242-09173F13E4C5
n5:Isoelectric-Point
n21:271B41BA-363D-11E5-9242-09173F13E4C5