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Namespace Prefixes

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Statements

Subject Item
n2:DB00048
rdf:type
n5:Drug
n5:description
The enzyme collagenase is derived from fermentation of Clostridium histolyticum
n5:dosage
n18:271B41AE-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Norris DB, Trudgill PW: Multiple forms of cyclohexanone oxygenase from Nocardia globerula CL1. Eur J Biochem. 1976 Mar 16;63(1):193-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4312 # Pajot P: Fluroescence of proteins in 6-M guanidine hydrochloride. A method for the quantitative determination of tryptophan. Eur J Biochem. 1976 Mar 16;63(1):263-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4317
n5:group
investigational approved
n5:indication
Used to promote debridement of necrotic tissue in the treatment of severe burns and dermal ulcers including decubitus ulcers.
owl:sameAs
n22:DB00048 n24:DB00048
dcterms:title
Collagenase
adms:identifier
n14:Collagenase n19:C00816 n20:DB00048 n23:PA449107
n5:mechanismOfAction
Collagenase is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing and metastasis, collagen becomes susceptible to cleavage by collagenases. Collagenase cleaves all 3 alpha helical chains of native Types I, II and III collagens at a single locus by hydrolyzing the peptide bond following the Gly residue of the sequence: Gly 775-(Ile or Leu) 776-(Ala or Leu) 777 located approximately three-fourths of the chain length from each N-terminus
n5:packager
n9:271B41A8-363D-11E5-9242-09173F13E4C5 n9:271B41A9-363D-11E5-9242-09173F13E4C5 n9:271B41A6-363D-11E5-9242-09173F13E4C5 n9:271B41A7-363D-11E5-9242-09173F13E4C5 n9:271B41A4-363D-11E5-9242-09173F13E4C5 n9:271B41A5-363D-11E5-9242-09173F13E4C5 n9:271B41A3-363D-11E5-9242-09173F13E4C5
n5:synonym
AA4500
n10:hasAHFSCode
n11:84-92-00
n5:synthesisReference
Hun-Chi Lin, Shau-Ping Lei, "Molecular cloning of the genes responsible for collagenase production from Clostridium histolyticum." U.S. Patent US5177017, issued December, 1972.
n3:hasConcept
n4:M0026363
foaf:page
n8:collagenase-ointment.html n16:collagenase.htm
n5:Molecular-Formula
n6:271B41B2-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B41B1-363D-11E5-9242-09173F13E4C5
n10:hasATCCode
n15:D03BA02
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
9001-12-1
n5:containedIn
n17:271B41AD-363D-11E5-9242-09173F13E4C5 n17:271B41AB-363D-11E5-9242-09173F13E4C5 n17:271B41AC-363D-11E5-9242-09173F13E4C5 n17:271B41AA-363D-11E5-9242-09173F13E4C5
n5:Hydrophobicity
n6:271B41AF-363D-11E5-9242-09173F13E4C5
n5:Isoelectric-Point
n6:271B41B0-363D-11E5-9242-09173F13E4C5