. . "Ig gamma-1 chain C region"@en . "26 days"@en . "# Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR, Gould HJ: Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol. 2003 Apr;33(4):1030-40. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/12672069"@en . . "242138-07-4"@en . . . . . . . "Omalizumab"@en . . . "A recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin."@en . . . . . "Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils."@en . . "investigational"@en . . " "@en . "approved"@en . "For treatment of asthma caused by allergies"@en . . . . "Liver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile."@en . "* 78 \u00B1 32 mL/kg"@en . . . "Humans and other mammals"@en . . . . .