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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n10http://linked.opendata.cz/resource/AHFS/
foafhttp://xmlns.com/foaf/0.1/
n16http://linked.opendata.cz/resource/mesh/concept/
n26http://linked.opendata.cz/resource/drugbank/company/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00043/identifier/drugbank/
n25http://linked.opendata.cz/resource/drugbank/dosage/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00043/identifier/national-drug-code-directory/
n14http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n12http://www.rxlist.com/cgi/generic/
n21http://linked.opendata.cz/resource/drugbank/patent/
n20http://linked.opendata.cz/resource/drugbank/drug/DB00043/identifier/genbank/
n4http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n22http://linked.opendata.cz/resource/drugbank/drug/DB00043/identifier/uniprotkb/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n6http://linked.opendata.cz/resource/drugbank/medicinal-product/
n5http://linked.opendata.cz/ontology/drugbank/
n15http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n18http://www.drugs.com/cdi/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00043/identifier/wikipedia/
n24http://linked.opendata.cz/resource/drugbank/drug/DB00043/identifier/pharmgkb/
n13http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n27http://linked.opendata.cz/resource/atc/
n9http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00043
rdf:type
n5:Drug
n5:description
A recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
n5:dosage
n25:271B415F-363D-11E5-9242-09173F13E4C5 n25:271B4160-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR, Gould HJ: Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol. 2003 Apr;33(4):1030-40. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12672069
n5:group
investigational approved
n5:halfLife
26 days
n5:indication
For treatment of asthma caused by allergies
owl:sameAs
n4:DB00043 n14:DB00043
dcterms:title
Omalizumab
adms:identifier
n8:DB00043 n19:50242-040-62 n20:J00228 n22:P01857 n23:Omalizumab n24:PA164752253
n5:mechanismOfAction
Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
n5:packager
n26:271B415C-363D-11E5-9242-09173F13E4C5 n26:271B415D-363D-11E5-9242-09173F13E4C5
n5:patent
n21:1340233 n21:2113813
n5:routeOfElimination
Liver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile.
n5:synonym
Ig gamma-1 chain C region
n5:volumeOfDistribution
* 78 ± 32 mL/kg
n9:hasAHFSCode
n10:48-92-00
n15:hasConcept
n16:M0387411
foaf:page
n12:xolair.htm n18:omalizumab.html
n5:Molecular-Formula
n13:271B4165-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n13:271B4164-363D-11E5-9242-09173F13E4C5
n9:hasATCCode
n27:R03DX05
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
242138-07-4
n5:category
n5:containedIn
n6:271B415E-363D-11E5-9242-09173F13E4C5
n5:Hydrophobicity
n13:271B4162-363D-11E5-9242-09173F13E4C5
n5:Isoelectric-Point
n13:271B4163-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n13:271B4161-363D-11E5-9242-09173F13E4C5