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Namespace Prefixes

PrefixIRI
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n20http://linked.opendata.cz/resource/drugbank/drug/DB00039/identifier/uniprotkb/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00039/identifier/wikipedia/
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n10http://www.drugs.com/cdi/
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n19http://linked.opendata.cz/resource/drugbank/drug/DB00039/identifier/national-drug-code-directory/
n13http://linked.opendata.cz/resource/atc/
n12http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00039
rdf:type
n3:Drug
n3:description
Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli.
n3:dosage
n7:271B412E-363D-11E5-9242-09173F13E4C5 n7:271B412F-363D-11E5-9242-09173F13E4C5
n3:generalReferences
#Lexicomp [Internet]. Palifermin. 2014 [cited 1 December 2014]. Available from: http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7429#f_interactions
n3:group
approved
n3:halfLife
Elimination half-life: 4.5 hours (range: 3.3-5.7 hours)
n3:indication
For treatment of oral mucositis associated with chemotherapy and radiation therapy.
owl:sameAs
n23:DB00039 n24:DB00039
dcterms:title
Palifermin
adms:identifier
n6:PA164744014 n8:Palifermin n17:DB00039 n19:55513-520-06 n20:P21781 n21:M60828
n3:mechanismOfAction
Kepivance binds to the human keratinocyte growth factor (KGF) receptor found on buccal cell surfaces. The binding activates a Ras-MapK (Map kinase) signaling pathway which leads to the transcriptional activation of many proteins important for cell growth and survival.
n3:packager
n11:271B412C-363D-11E5-9242-09173F13E4C5 n11:271B412A-363D-11E5-9242-09173F13E4C5 n11:271B412B-363D-11E5-9242-09173F13E4C5
n3:synonym
Fibroblast growth factor- 7 KGF HBGF-7 FGF-7 Keratinocyte growth factor precursor
n12:hasAHFSCode
n25:84-16-00
n14:hasConcept
n15:M0521761
foaf:page
n10:palifermin.html n16:kepivance.htm
n3:Molecular-Formula
n4:271B4133-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4132-363D-11E5-9242-09173F13E4C5
n12:hasATCCode
n13:V03AF08
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
162394-19-6
n3:category
n3:containedIn
n26:271B412D-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n4:271B4130-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B4131-363D-11E5-9242-09173F13E4C5