. . "AGIF"@en . . . . . . "145941-26-0"@en . "Oprelvekin, the active ingredient in Neumega\u00AE is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo. The primary hematopoietic activity of Neumega\u00AE is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega\u00AE has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega\u00AE improved platelet nadirs and accelerated platelet recoveries compared to controls. In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines."@en . . . "Interleukin-11 precursor"@en . . "Increases reduced platelet levels due to chemotherapy"@en . "IL-11"@en . "investigational"@en . "Absolute bioavailability is over 80%."@en . . . . " "@en . "Oprelvekin binds to the interleukin 11 receptor which leads to a cascade of signal transduction events. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production."@en . . "Humans and other mammals"@en . "Oprelvekin"@en . "approved"@en . . "6.9 +/- 1.7 hrs"@en . "The kidney is the primary route of elimination. The amount of intact Neumega in urine was low, indicating that the molecule was metabolized before excretion."@en . . "Adipogenesis inhibitory factor"@en . . . . . .