. . . . " "@en . . "Eptacog alfa"@en . . . "Proconvertin"@en . "Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form."@en . . . . . . "Humans and other mammals"@en . "For treatment of hemorrhagic complications in hemophilia A and B"@en . . . . . . "NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin."@en . . "9001-25-6"@en . . . "Coagulation factor VII precursor"@en . . "# Blackshear PJ, Holloway PA, Alberti KG: Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine. Biochem J. 1975 Sep;150(3):379-87. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/2155 # Roberts HR, Monroe DM, White GC: The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood. 2004 Dec 15;104(13):3858-64. Epub 2004 Aug 24. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15328151 # Kenet G, Walden R, Eldad A, Martinowitz U: Treatment of traumatic bleeding with recombinant factor VIIa. Lancet. 1999 Nov 27;354(9193):1879. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10584732 # O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM: Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006 Jan 18;295(3):293-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/16418464 # Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T: Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005 Feb 24;352(8):777-85. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/15728810"@en . "* 121 \u00B1 30 mL/kg [adults] * 153 \u00B1 29 mL/kg [children] * 280 to 290 mL/kg [congenital Factor VII deficiency]"@en . "approved"@en . "* 33 - 37 mL/h x kg [healthy] * 1375 +/- 396 mL/hr [severe hemophilia A male children] * 57.3 +/- 9.5 mL/hr/kg [severe hemophilia A male children] * 2767 +/- 385 mL/hr [severe hemophilia A men] * 37.6 +/- 13.1 mL/hr/kg [severe hemophilia A men]"@en . "SPCA"@en . . "Coagulation factor VIIa"@en . . . "Serum prothrombin conversion accelerator"@en .