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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB00036
rdf:type
n3:Drug
n3:description
Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
n3:dosage
n4:271B411C-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Blackshear PJ, Holloway PA, Alberti KG: Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine. Biochem J. 1975 Sep;150(3):379-87. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2155 # Roberts HR, Monroe DM, White GC: The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood. 2004 Dec 15;104(13):3858-64. Epub 2004 Aug 24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15328151 # Kenet G, Walden R, Eldad A, Martinowitz U: Treatment of traumatic bleeding with recombinant factor VIIa. Lancet. 1999 Nov 27;354(9193):1879. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10584732 # O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM: Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006 Jan 18;295(3):293-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16418464 # Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T: Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005 Feb 24;352(8):777-85. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15728810
n3:group
approved
n3:indication
For treatment of hemorrhagic complications in hemophilia A and B
owl:sameAs
n18:DB00036 n22:DB00036
dcterms:title
Coagulation factor VIIa
adms:identifier
n12:DB00036 n13:M13232 n14:0169-7010-01 n19:P08709 n20:C03378 n21:D00172 n24:PA164748389 n25:Factor_VII
n3:mechanismOfAction
NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin.
n3:packager
n8:271B4118-363D-11E5-9242-09173F13E4C5
n3:synonym
Eptacog alfa Proconvertin Coagulation factor VII precursor SPCA Serum prothrombin conversion accelerator
n3:volumeOfDistribution
* 121 ± 30 mL/kg [adults] * 153 ± 29 mL/kg [children] * 280 to 290 mL/kg [congenital Factor VII deficiency]
n15:hasConcept
n16:M0024390
foaf:page
n7:novoseven.htm n10:coagulation-factor-viia-recombinant.html
n3:Molecular-Formula
n9:271B4121-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n9:271B4120-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9001-25-6
n3:category
n3:clearance
* 33 - 37 mL/h x kg [healthy] * 1375 +/- 396 mL/hr [severe hemophilia A male children] * 57.3 +/- 9.5 mL/hr/kg [severe hemophilia A male children] * 2767 +/- 385 mL/hr [severe hemophilia A men] * 37.6 +/- 13.1 mL/hr/kg [severe hemophilia A men]
n3:containedIn
n5:271B411B-363D-11E5-9242-09173F13E4C5 n5:271B4119-363D-11E5-9242-09173F13E4C5 n5:271B411A-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n9:271B411E-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n9:271B411F-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n9:271B411D-363D-11E5-9242-09173F13E4C5