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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB00024
rdf:type
n3:Drug
n3:description
Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit is nearly identical to that of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The alpha subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The beta subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
n3:dosage
n23:271B3FF3-363D-11E5-9242-09173F13E4C5 n23:271B3FF4-363D-11E5-9242-09173F13E4C5 n23:271B3FF5-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Lexicomp #Product label
n3:group
approved
n3:halfLife
25 ± 10 hours
n3:indication
For detection of residueal or recurrent thyroid cancer
n3:manufacturer
n4:271B3FF1-363D-11E5-9242-09173F13E4C5 n4:271B3FF0-363D-11E5-9242-09173F13E4C5
owl:sameAs
n14:DB00024 n24:DB00024
dcterms:title
Thyrotropin Alfa
adms:identifier
n10:PA164746560 n11:P01225 n19:DB00024 n20:58468-1849-4 n22:M16647
n3:mechanismOfAction
Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging.
n3:packager
n4:271B3FEE-363D-11E5-9242-09173F13E4C5 n4:271B3FEF-363D-11E5-9242-09173F13E4C5
n3:patent
n15:5840566
n3:routeOfElimination
kidney and liver
n3:synonym
Thyrotrophin-alfa rTSH Thyrotropin Thyrotropin-alpha Thytrophin Thyrotrophin-alpha TSH Thyrotropin-a Thyroid stimulating hormone
n3:toxicity
No difference in efficacy and toxicity between adult and geriatric patients. No studies in lactating women, pregnant women and pediatrics. Cautionary administration is advised.
n16:hasAHFSCode
n21:36-60-00
n3:synthesisReference
19366632
n5:hasConcept
n6:M0534260
foaf:page
n8:thyrotropin-alfa.html n26:thyrotropin.htm
n3:Molecular-Formula
n18:271B3FFA-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n18:271B3FF9-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n17:H01AB01
n3:absorption
Time to peak: Median: 10 hours (range: 3-24 hours) After a single intramuscular injection of 0.9 mg of thyrotropin alfa: Cmax= 116+38mU/L, Tmax=22+8.5 hours. AUC=5088+1728 mU·hr/L.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9002-71-5
n3:category
n3:containedIn
n12:271B3FF2-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n18:271B3FF7-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n18:271B3FF8-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n18:271B3FF6-363D-11E5-9242-09173F13E4C5