. . . . . . . "Martin Bickel, Rolf Geiger, Richard Leeb, Walter Petri, \"Secretin preparations with intensified and protracted action, process for their manufacture, their use as well as dihydroxybenzoyl-L-tyrosine.\" U.S. Patent US4302448, issued August, 1964."@en . "investigational"@en . "For diagnosis of pancreatic exocrine dysfunction and gastrinoma"@en . "This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine\u2019s contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered."@en . . . . "Secretin"@en . . "approved"@en . . . . . "Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone"@en . . "Humans and other mammals"@en . . . " "@en .