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Namespace Prefixes

PrefixIRI
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n4http://linked.opendata.cz/resource/drugbank/company/
n20http://www.drugs.com/
n19http://bio2rdf.org/drugbank:
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n21http://linked.opendata.cz/resource/drugbank/drug/DB00021/identifier/pharmgkb/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00021/identifier/wikipedia/
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n6http://linked.opendata.cz/resource/atc/
n5http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00021
rdf:type
n3:Drug
n3:description
This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine’s contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
n3:group
investigational approved
n3:indication
For diagnosis of pancreatic exocrine dysfunction and gastrinoma
n3:manufacturer
n4:271B3FC4-363D-11E5-9242-09173F13E4C5 n4:271B3FC5-363D-11E5-9242-09173F13E4C5
owl:sameAs
n14:DB00021 n19:DB00021
dcterms:title
Secretin
adms:identifier
n8:Secretin n18:DB00021 n21:PA164760844
n3:mechanismOfAction
Secretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone
n3:packager
n4:271B3FC3-363D-11E5-9242-09173F13E4C5
n3:synthesisReference
Martin Bickel, Rolf Geiger, Richard Leeb, Walter Petri, "Secretin preparations with intensified and protracted action, process for their manufacture, their use as well as dihydroxybenzoyl-L-tyrosine." U.S. Patent US4302448, issued August, 1964.
n15:hasConcept
n16:M0019589
foaf:page
n11:secretin.htm n20:human_secretin.html
n3:Molecular-Formula
n9:271B3FCA-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n9:271B3FC9-363D-11E5-9242-09173F13E4C5
n5:hasATCCode
n6:V04CK01
n3:affectedOrganism
Humans and other mammals
n3:category
n3:containedIn
n12:271B3FC6-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n9:271B3FC7-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n9:271B3FC8-363D-11E5-9242-09173F13E4C5