. . . . . . . . . . . "investigational"@en . "Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils"@en . . . . "approved"@en . "* 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)] * 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)] * 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)] * 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]"@en . . "Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein."@en . "Kaname Sugimoto, \"Process for the production of human colony-stimulating factor.\" U.S. Patent US4621050, issued May, 1983."@en . . . . " "@en . "Sargramostim"@en . "83869-56-1"@en . . . . . "GM-CSF"@en . . "For the treatment of cancer and bone marrow transplant"@en . . . . . "Humans and other mammals"@en .