This HTML5 document contains 19 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
foafhttp://xmlns.com/foaf/0.1/
n8http://linked.opendata.cz/resource/drugbank/company/
n10http://bio2rdf.org/drugbank:
n11http://linked.opendata.cz/resource/drugbank/drug/DB00018/identifier/pharmgkb/
admshttp://www.w3.org/ns/adms#
n7http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n9http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n13http://www.drugs.com/cdi/
n14http://linked.opendata.cz/resource/drugbank/property/
n5http://linked.opendata.cz/resource/drugbank/drug/DB00018/identifier/drugbank/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB00018
rdf:type
n3:Drug
n3:description
Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
n3:generalReferences
# Sturgill MG, Rashidbaigi A, Liao MJ, Zhao XX, Hua J, Trout R, Knill JR, Grasing KW: Extravascular administration of interferon alfa-N3 increases serum exposure and 2-5(A) synthetase activity. J Clin Pharmacol. 2000 Jun;40(6):606-15. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10868311
n3:group
investigational approved
n3:indication
For the intralesional treatment of refractory or recurring external condylomata acuminata.
owl:sameAs
n7:DB00018 n10:DB00018
dcterms:title
Interferon alfa-n3
adms:identifier
n5:DB00018 n11:PA164746228
n3:mechanismOfAction
Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
n3:packager
n8:271B3FA7-363D-11E5-9242-09173F13E4C5
foaf:page
n13:interferon-alfa-n3-solution.html
n3:affectedOrganism
Humans and other mammals
n3:category
n3:containedIn
n9:271B3FA8-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n14:271B3FAA-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n14:271B3FA9-363D-11E5-9242-09173F13E4C5